Mapping nonlinear receptive field structure in primate retina at single cone resolution

Jeremy Freeman, Greg D. Field, Peter H. Li, Martin Greschner, Deborah E. Gunning, Keith Mathieson, Alexander Sher, Alan M. Litke, Liam Paninski, Eero Simoncelli, E. J. Chichilnisky

Research output: Contribution to journalArticle

Abstract

The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals flowing from the input to the output of the primate retina, using a combination of large-scale multi-electrode recordings from an identified ganglion cell type, visual stimulation targeted at individual cone photoreceptors, and a hierarchical computational model. The results reveal nonlinear subunits in the circuity of OFF midget ganglion cells, which subserve high-resolution vision. The model explains light responses to a variety of stimuli more accurately than a linear model, including stimuli targeted to cones within and across subunits. The recovered model components are consistent with known anatomical organization of midget bipolar interneurons. These results reveal the spatial structure of linear and nonlinear encoding, at the resolution of single cells and at the scale of complete circuits.

Original languageEnglish (US)
Article numbere05241
JournaleLife
Volume4
Issue numberOCTOBER2015
DOIs
StatePublished - Oct 30 2015

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Primates
Retina
Cones
Interneurons
Ganglia
Retinal Cone Photoreceptor Cells
Photic Stimulation
Networks (circuits)
Linear Models
Electrodes
Light

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Freeman, J., Field, G. D., Li, P. H., Greschner, M., Gunning, D. E., Mathieson, K., ... Chichilnisky, E. J. (2015). Mapping nonlinear receptive field structure in primate retina at single cone resolution. eLife, 4(OCTOBER2015), [e05241]. https://doi.org/10.7554/eLife.05241

Mapping nonlinear receptive field structure in primate retina at single cone resolution. / Freeman, Jeremy; Field, Greg D.; Li, Peter H.; Greschner, Martin; Gunning, Deborah E.; Mathieson, Keith; Sher, Alexander; Litke, Alan M.; Paninski, Liam; Simoncelli, Eero; Chichilnisky, E. J.

In: eLife, Vol. 4, No. OCTOBER2015, e05241, 30.10.2015.

Research output: Contribution to journalArticle

Freeman, J, Field, GD, Li, PH, Greschner, M, Gunning, DE, Mathieson, K, Sher, A, Litke, AM, Paninski, L, Simoncelli, E & Chichilnisky, EJ 2015, 'Mapping nonlinear receptive field structure in primate retina at single cone resolution', eLife, vol. 4, no. OCTOBER2015, e05241. https://doi.org/10.7554/eLife.05241
Freeman J, Field GD, Li PH, Greschner M, Gunning DE, Mathieson K et al. Mapping nonlinear receptive field structure in primate retina at single cone resolution. eLife. 2015 Oct 30;4(OCTOBER2015). e05241. https://doi.org/10.7554/eLife.05241
Freeman, Jeremy ; Field, Greg D. ; Li, Peter H. ; Greschner, Martin ; Gunning, Deborah E. ; Mathieson, Keith ; Sher, Alexander ; Litke, Alan M. ; Paninski, Liam ; Simoncelli, Eero ; Chichilnisky, E. J. / Mapping nonlinear receptive field structure in primate retina at single cone resolution. In: eLife. 2015 ; Vol. 4, No. OCTOBER2015.
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