Mapk establishes a molecular context that defines effective training patterns for long-term memory formation

Gary T. Philips, Xiaojing Ye, Ashley M. Kopec, Thomas J. Carew

Research output: Contribution to journalArticle


Although the importance of spaced training trials in the formation of long-term memory (LTM) is widely appreciated, surprisingly little is known about the molecular mechanisms that support interactions between individual trials. The intertrial dynamics of ERK/MAPK activation have recently been correlated with effective training patterns for LTM. However, whether and how MAPK is required to mediate intertrial interactions remains unknown. Using a novel two-trial training pattern which inducesLTMin Aplysia,we show that the first of two training trials recruits delayed protein synthesis-dependent nuclear MAPK activity that establishes a unique molecular context involving the recruitment of CREB kinase and ApC/EBP and is an essential intertrial signaling mechanism for LTM induction. These findings provide the first demonstration of a requirement for MAPK in the intertrial interactions during memory formation and suggest that the kinetics of MAPK activation following individual experiences determines effective training intervals for LTM formation.

Original languageEnglish (US)
Pages (from-to)7565-7573
Number of pages9
JournalJournal of Neuroscience
Issue number17
StatePublished - Apr 24 2013


ASJC Scopus subject areas

  • Neuroscience(all)

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