Manipulating crystallization with molecular additives

Alexander G. Shtukenberg, Stephanie S. Lee, Bart Kahr, Michael Ward

Research output: Contribution to journalArticle

Abstract

Given the importance of organic crystals in a wide range of industrial applications, the chemistry, biology, materials science, and chemical engineering communities have focused considerable attention on developing methods to control crystal structure, size, shape, and orientation. Tailored additives have been used to control crystallization to great effect, presumably by selectively binding to particular crystallographic surfaces and sites. However, substantial knowledge gaps still exist in the fundamental mechanisms that govern the formation and growth of organic crystals in both the absence and presence of additives. In this review, we highlight research discoveries that reveal the role of additives, either introduced by design or present adventitiously, on various stages of formation and growth of organic crystals, including nucleation, dislocation spiral growth mechanisms, growth inhibition, and nonclassical crystal morphologies. The insights from these investigations and others of their kind are likely to guide the development of innovative methods to manipulate crystallization for a wide range of materials and applications.

Original languageEnglish (US)
Pages (from-to)77-96
Number of pages20
JournalAnnual Review of Chemical and Biomolecular Engineering
Volume5
DOIs
StatePublished - 2014

Fingerprint

Crystallization
Crystals
Chemical engineering
Materials science
Dislocations (crystals)
Crystal orientation
Industrial applications
Nucleation
Crystal structure

Keywords

  • Critical nucleus size
  • Dislocation generation
  • Nanoconfined crystallization
  • Polymorphism
  • Tailor-made additives
  • Twisted crystals

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment
  • Chemistry(all)

Cite this

Manipulating crystallization with molecular additives. / Shtukenberg, Alexander G.; Lee, Stephanie S.; Kahr, Bart; Ward, Michael.

In: Annual Review of Chemical and Biomolecular Engineering, Vol. 5, 2014, p. 77-96.

Research output: Contribution to journalArticle

@article{102f5420c70c4b2c9085c07a4cb1224b,
title = "Manipulating crystallization with molecular additives",
abstract = "Given the importance of organic crystals in a wide range of industrial applications, the chemistry, biology, materials science, and chemical engineering communities have focused considerable attention on developing methods to control crystal structure, size, shape, and orientation. Tailored additives have been used to control crystallization to great effect, presumably by selectively binding to particular crystallographic surfaces and sites. However, substantial knowledge gaps still exist in the fundamental mechanisms that govern the formation and growth of organic crystals in both the absence and presence of additives. In this review, we highlight research discoveries that reveal the role of additives, either introduced by design or present adventitiously, on various stages of formation and growth of organic crystals, including nucleation, dislocation spiral growth mechanisms, growth inhibition, and nonclassical crystal morphologies. The insights from these investigations and others of their kind are likely to guide the development of innovative methods to manipulate crystallization for a wide range of materials and applications.",
keywords = "Critical nucleus size, Dislocation generation, Nanoconfined crystallization, Polymorphism, Tailor-made additives, Twisted crystals",
author = "Shtukenberg, {Alexander G.} and Lee, {Stephanie S.} and Bart Kahr and Michael Ward",
year = "2014",
doi = "10.1146/annurev-chembioeng-061312-103308",
language = "English (US)",
volume = "5",
pages = "77--96",
journal = "Annual Review of Chemical and Biomolecular Engineering",
issn = "1947-5438",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Manipulating crystallization with molecular additives

AU - Shtukenberg, Alexander G.

AU - Lee, Stephanie S.

AU - Kahr, Bart

AU - Ward, Michael

PY - 2014

Y1 - 2014

N2 - Given the importance of organic crystals in a wide range of industrial applications, the chemistry, biology, materials science, and chemical engineering communities have focused considerable attention on developing methods to control crystal structure, size, shape, and orientation. Tailored additives have been used to control crystallization to great effect, presumably by selectively binding to particular crystallographic surfaces and sites. However, substantial knowledge gaps still exist in the fundamental mechanisms that govern the formation and growth of organic crystals in both the absence and presence of additives. In this review, we highlight research discoveries that reveal the role of additives, either introduced by design or present adventitiously, on various stages of formation and growth of organic crystals, including nucleation, dislocation spiral growth mechanisms, growth inhibition, and nonclassical crystal morphologies. The insights from these investigations and others of their kind are likely to guide the development of innovative methods to manipulate crystallization for a wide range of materials and applications.

AB - Given the importance of organic crystals in a wide range of industrial applications, the chemistry, biology, materials science, and chemical engineering communities have focused considerable attention on developing methods to control crystal structure, size, shape, and orientation. Tailored additives have been used to control crystallization to great effect, presumably by selectively binding to particular crystallographic surfaces and sites. However, substantial knowledge gaps still exist in the fundamental mechanisms that govern the formation and growth of organic crystals in both the absence and presence of additives. In this review, we highlight research discoveries that reveal the role of additives, either introduced by design or present adventitiously, on various stages of formation and growth of organic crystals, including nucleation, dislocation spiral growth mechanisms, growth inhibition, and nonclassical crystal morphologies. The insights from these investigations and others of their kind are likely to guide the development of innovative methods to manipulate crystallization for a wide range of materials and applications.

KW - Critical nucleus size

KW - Dislocation generation

KW - Nanoconfined crystallization

KW - Polymorphism

KW - Tailor-made additives

KW - Twisted crystals

UR - http://www.scopus.com/inward/record.url?scp=84902441755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902441755&partnerID=8YFLogxK

U2 - 10.1146/annurev-chembioeng-061312-103308

DO - 10.1146/annurev-chembioeng-061312-103308

M3 - Article

C2 - 24579880

AN - SCOPUS:84902441755

VL - 5

SP - 77

EP - 96

JO - Annual Review of Chemical and Biomolecular Engineering

JF - Annual Review of Chemical and Biomolecular Engineering

SN - 1947-5438

ER -