TY - JOUR
T1 - Malaria in India
T2 - The Center for the Study of Complex Malaria in India
AU - Das, Aparup
AU - Anvikar, Anupkumar R.
AU - Cator, Lauren J.
AU - Dhiman, Ramesh C.
AU - Eapen, Alex
AU - Mishra, Neelima
AU - Nagpal, Bhupinder N.
AU - Nanda, Nutan
AU - Raghavendra, Kamaraju
AU - Read, Andrew F.
AU - Sharma, Surya K.
AU - Singh, Om P.
AU - Singh, Vineeta
AU - Sinnis, Photini
AU - Srivastava, Harish C.
AU - Sullivan, Steven A.
AU - Sutton, Patrick L.
AU - Thomas, Matthew B.
AU - Carlton, Jane M.
AU - Valecha, Neena
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Malaria is a major public health problem in India and one which contributes significantly to the overall malaria burden in Southeast Asia. The National Vector Borne Disease Control Program of India reported ∼1.6 million cases and ∼1100 malaria deaths in 2009. Some experts argue that this is a serious underestimation and that the actual number of malaria cases per year is likely between 9 and 50 times greater, with an approximate 13-fold underestimation of malaria-related mortality. The difficulty in making these estimations is further exacerbated by (i) highly variable malaria eco-epidemiological profiles, (ii) the transmission and overlap of multiple Plasmodium species and Anopheles vectors, (iii) increasing antimalarial drug resistance and insecticide resistance, and (iv) the impact of climate change on each of these variables. Simply stated, the burden of malaria in India is complex. Here we describe plans for a Center for the Study of Complex Malaria in India (CSCMi), one of ten International Centers of Excellence in Malaria Research (ICEMRs) located in malarious regions of the world recently funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health. The CSCMi is a close partnership between Indian and United States scientists, and aims to address major gaps in our understanding of the complexity of malaria in India, including changing patterns of epidemiology, vector biology and control, drug resistance, and parasite genomics. We hope that such a multidisciplinary approach that integrates clinical and field studies with laboratory, molecular, and genomic methods will provide a powerful combination for malaria control and prevention in India.
AB - Malaria is a major public health problem in India and one which contributes significantly to the overall malaria burden in Southeast Asia. The National Vector Borne Disease Control Program of India reported ∼1.6 million cases and ∼1100 malaria deaths in 2009. Some experts argue that this is a serious underestimation and that the actual number of malaria cases per year is likely between 9 and 50 times greater, with an approximate 13-fold underestimation of malaria-related mortality. The difficulty in making these estimations is further exacerbated by (i) highly variable malaria eco-epidemiological profiles, (ii) the transmission and overlap of multiple Plasmodium species and Anopheles vectors, (iii) increasing antimalarial drug resistance and insecticide resistance, and (iv) the impact of climate change on each of these variables. Simply stated, the burden of malaria in India is complex. Here we describe plans for a Center for the Study of Complex Malaria in India (CSCMi), one of ten International Centers of Excellence in Malaria Research (ICEMRs) located in malarious regions of the world recently funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health. The CSCMi is a close partnership between Indian and United States scientists, and aims to address major gaps in our understanding of the complexity of malaria in India, including changing patterns of epidemiology, vector biology and control, drug resistance, and parasite genomics. We hope that such a multidisciplinary approach that integrates clinical and field studies with laboratory, molecular, and genomic methods will provide a powerful combination for malaria control and prevention in India.
KW - Anopheles
KW - Epidemiology
KW - Genomics
KW - India
KW - Malaria
KW - Plasmodium
UR - http://www.scopus.com/inward/record.url?scp=84863419288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863419288&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2011.11.008
DO - 10.1016/j.actatropica.2011.11.008
M3 - Article
C2 - 22142788
AN - SCOPUS:84863419288
VL - 121
SP - 267
EP - 273
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 3
ER -