Making synaptic plasticity and memory last: Mechanisms of translational regulation

Joel D. Richter, Eric Klann

Research output: Contribution to journalArticle

Abstract

Synaptic transmission in neurons is a measure of communication at synapses, the points of contact between axons and dendrites. The magnitude of synaptic transmission is a reflection of the strength of these synaptic connections, which in turn can be altered by the frequency with which the synapses are stimulated, the arrival of stimuli from other neurons in the appropriate temporal window, and by neurotrophic factors and neuromodulators. The ability of synapses to undergo lasting biochemical and morphological changes in response to these types of stimuli and neuromodulators is known as synaptic plasticity, which likely forms the cellular basis for learning and memory, although the relationship between any one form synaptic plasticity and a particular type of memory is unclear. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, several types of memory formation and consolidation. Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalGenes & development
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Neuronal Plasticity
Synapses
Synaptic Transmission
Neurotransmitter Agents
Neurons
Aptitude
Nerve Growth Factors
Protein Biosynthesis
Dendrites
Axons
Communication
Learning
RNA

Keywords

  • Memory
  • Neuron
  • Synaptic plasticity
  • Translation

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Making synaptic plasticity and memory last : Mechanisms of translational regulation. / Richter, Joel D.; Klann, Eric.

In: Genes & development, Vol. 23, No. 1, 01.01.2009, p. 1-11.

Research output: Contribution to journalArticle

@article{59c8353cf8324f23b2781ead1e4cecbe,
title = "Making synaptic plasticity and memory last: Mechanisms of translational regulation",
abstract = "Synaptic transmission in neurons is a measure of communication at synapses, the points of contact between axons and dendrites. The magnitude of synaptic transmission is a reflection of the strength of these synaptic connections, which in turn can be altered by the frequency with which the synapses are stimulated, the arrival of stimuli from other neurons in the appropriate temporal window, and by neurotrophic factors and neuromodulators. The ability of synapses to undergo lasting biochemical and morphological changes in response to these types of stimuli and neuromodulators is known as synaptic plasticity, which likely forms the cellular basis for learning and memory, although the relationship between any one form synaptic plasticity and a particular type of memory is unclear. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, several types of memory formation and consolidation. Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation.",
keywords = "Memory, Neuron, Synaptic plasticity, Translation",
author = "Richter, {Joel D.} and Eric Klann",
year = "2009",
month = "1",
day = "1",
doi = "10.1101/gad.1735809",
language = "English (US)",
volume = "23",
pages = "1--11",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "1",

}

TY - JOUR

T1 - Making synaptic plasticity and memory last

T2 - Mechanisms of translational regulation

AU - Richter, Joel D.

AU - Klann, Eric

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Synaptic transmission in neurons is a measure of communication at synapses, the points of contact between axons and dendrites. The magnitude of synaptic transmission is a reflection of the strength of these synaptic connections, which in turn can be altered by the frequency with which the synapses are stimulated, the arrival of stimuli from other neurons in the appropriate temporal window, and by neurotrophic factors and neuromodulators. The ability of synapses to undergo lasting biochemical and morphological changes in response to these types of stimuli and neuromodulators is known as synaptic plasticity, which likely forms the cellular basis for learning and memory, although the relationship between any one form synaptic plasticity and a particular type of memory is unclear. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, several types of memory formation and consolidation. Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation.

AB - Synaptic transmission in neurons is a measure of communication at synapses, the points of contact between axons and dendrites. The magnitude of synaptic transmission is a reflection of the strength of these synaptic connections, which in turn can be altered by the frequency with which the synapses are stimulated, the arrival of stimuli from other neurons in the appropriate temporal window, and by neurotrophic factors and neuromodulators. The ability of synapses to undergo lasting biochemical and morphological changes in response to these types of stimuli and neuromodulators is known as synaptic plasticity, which likely forms the cellular basis for learning and memory, although the relationship between any one form synaptic plasticity and a particular type of memory is unclear. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, several types of memory formation and consolidation. Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation.

KW - Memory

KW - Neuron

KW - Synaptic plasticity

KW - Translation

UR - http://www.scopus.com/inward/record.url?scp=58149485508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149485508&partnerID=8YFLogxK

U2 - 10.1101/gad.1735809

DO - 10.1101/gad.1735809

M3 - Article

C2 - 19136621

AN - SCOPUS:58149485508

VL - 23

SP - 1

EP - 11

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 1

ER -