Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus

H. Scherberger, I. Fineman, S. Musallam, D. J. Dubowitz, K. A. Bernheim, Bijan Pesaran, B. D. Corneil, B. Gilliken, R. A. Andersen

Research output: Contribution to journalArticle

Abstract

The implantation of chronic recording electrodes in the brain has been shown to be a valuable method for simultaneously recording from many neurons. However, precise placement of these electrodes, crucial for successful recording, is challenging if the target area is not on the brain surface. Here we present a stereotaxic implantation procedure to chronically implant bundles of recording electrodes into macaque cortical sulci, employing magnetic resonance (MR) imaging to determine stereotaxic coordinates of target location and sulcus orientation. Using this method in four animals, we recorded simultaneously the spiking activity and the local field potential from the parietal reach region (PRR), located in the medial bank of the intraparietal sulcus (IPS), while the animal performed a reach movement task. Fifty percent of all electrodes recorded spiking activity during the first 2 post-operative months, indicating their placement within cortical gray matter. Chronic neural activity was similar to standard single electrode recordings in PRR, as reported previously. These results indicate that this MR image-guided implantation technique can provide sufficient placement accuracy in cortical sulci and subcortical structures. Moreover, this technique may be useful for future cortical prosthesis applications in humans that require implants within sulci.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Neuroscience Methods
Volume130
Issue number1
DOIs
StatePublished - Nov 30 2003

Fingerprint

Parietal Lobe
Macaca
Electrodes
Magnetic Resonance Spectroscopy
Brain
Prostheses and Implants
Magnetic Resonance Imaging
Neurons

Keywords

  • Magnetic resonance imaging
  • Microwire electrodes
  • Neural prosthesis
  • Parietal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus. / Scherberger, H.; Fineman, I.; Musallam, S.; Dubowitz, D. J.; Bernheim, K. A.; Pesaran, Bijan; Corneil, B. D.; Gilliken, B.; Andersen, R. A.

In: Journal of Neuroscience Methods, Vol. 130, No. 1, 30.11.2003, p. 1-8.

Research output: Contribution to journalArticle

Scherberger, H, Fineman, I, Musallam, S, Dubowitz, DJ, Bernheim, KA, Pesaran, B, Corneil, BD, Gilliken, B & Andersen, RA 2003, 'Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus', Journal of Neuroscience Methods, vol. 130, no. 1, pp. 1-8. https://doi.org/10.1016/S0165-0270(03)00190-0
Scherberger, H. ; Fineman, I. ; Musallam, S. ; Dubowitz, D. J. ; Bernheim, K. A. ; Pesaran, Bijan ; Corneil, B. D. ; Gilliken, B. ; Andersen, R. A. / Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus. In: Journal of Neuroscience Methods. 2003 ; Vol. 130, No. 1. pp. 1-8.
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