Lymphocyte subpopulations in Down's syndrome: High percentage of circulating HNK-1+, Leu 2a+ cells

R. Maccario, A. G. Ugazio, L. Nespoli, Cristina Alberini, D. Montagna, F. Porta, F. Bonetti, G. R. Burgio

Research output: Contribution to journalArticle

Abstract

Peripheral blood lymphomononuclear cells (PBL) from 35 patients with Down's syndrome (DS, trisomy-21; 25 institutionalized and 10 non-institutionalized) were phenotypically characterized by means of various monoclonal antibodies. They included a high percentage of T lymphocytes with low avidity for sheep erythrocytes as well as an extremely high percentage of HNK-1+ cells and of lymphocytes reacting with the OKT8 and Leu 2a antibodies. The HNK-1+ cells of DS include four different subsets: (a) E+, OKT3+, OKT8-, Leu 2a-; (b) E+, OKT3+, OKT8+, Leu 2a+; (c) E-, OKT3-, OKT8-, Leu 2a- and (d) E-, OKT3-, OKT8+, Leu 2a+. Subsets (a) and (c) are also present in PBL from karyotypically normal controls while subsets (b) and (d) have a phenotype which has not been previously reported. These findings may be related to the triple expression by trisomic cells of the receptor for interferon, which is coded by a gene located on chromosome number 21. Alternatively, the high number of 'immature' NK cells of DS, possibly identical with pre-T lymphocytes, may originate from the congenital thymic derangement associated with trisomy 21.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalClinical and Experimental Immunology
Volume57
Issue number1
StatePublished - 1984

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Muromonab-CD3
Lymphocyte Subsets
Down Syndrome
Blood Cells
Interferon Receptors
T-Lymphocytes
Chromosomes, Human, Pair 21
Natural Killer Cells
Sheep
Erythrocytes
Monoclonal Antibodies
Lymphocytes
Phenotype
Antibodies
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Maccario, R., Ugazio, A. G., Nespoli, L., Alberini, C., Montagna, D., Porta, F., ... Burgio, G. R. (1984). Lymphocyte subpopulations in Down's syndrome: High percentage of circulating HNK-1+, Leu 2a+ cells. Clinical and Experimental Immunology, 57(1), 220-226.

Lymphocyte subpopulations in Down's syndrome : High percentage of circulating HNK-1+, Leu 2a+ cells. / Maccario, R.; Ugazio, A. G.; Nespoli, L.; Alberini, Cristina; Montagna, D.; Porta, F.; Bonetti, F.; Burgio, G. R.

In: Clinical and Experimental Immunology, Vol. 57, No. 1, 1984, p. 220-226.

Research output: Contribution to journalArticle

Maccario, R, Ugazio, AG, Nespoli, L, Alberini, C, Montagna, D, Porta, F, Bonetti, F & Burgio, GR 1984, 'Lymphocyte subpopulations in Down's syndrome: High percentage of circulating HNK-1+, Leu 2a+ cells', Clinical and Experimental Immunology, vol. 57, no. 1, pp. 220-226.
Maccario, R. ; Ugazio, A. G. ; Nespoli, L. ; Alberini, Cristina ; Montagna, D. ; Porta, F. ; Bonetti, F. ; Burgio, G. R. / Lymphocyte subpopulations in Down's syndrome : High percentage of circulating HNK-1+, Leu 2a+ cells. In: Clinical and Experimental Immunology. 1984 ; Vol. 57, No. 1. pp. 220-226.
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