Low Vitamin D levels predict clinical features of schizophrenia

Kristina Cieslak, Jordyn Feingold, Daniel Antonius, Julie Walsh-Messinger, Roberta Dracxler, Mary Rosedale, Nicole Aujero, David Keefe, Deborah Goetz, Raymond Goetz, Dolores Malaspina

Research output: Contribution to journalArticle

Abstract

Vitamin D plays crucial roles in neuroprotection and neurodevelopment, and low levels are commonly associated with schizophrenia. We considered if the association was spurious or causal by examining the association of Vitamin D with Leukocyte Telomere Length (LTL), a marker of cellular aging. Vitamin D levels in 22 well-characterized schizophrenia cases were examined with respect to symptoms, cognition, and functioning. LTL was assessed using quantitative polymerase chain reaction (qPCR). The results showed that 91% (20) had deficient or insufficient Vitamin D levels, which were associated with excitement and grandiosity, social anhedonia, and poverty of speech. Sex-specific analyses showed strong associations of hypovitamintosis D to negative symptoms and decreased premorbid adjustment in males, and to lesser hallucinations and emotional withdrawal, but increased anti-social aggression in females. In females LTL was furthermore associated with Vitamin D levels. This study demonstrates a relationship of low vitamin D levels with increased cellular aging in females. It is also the first study to demonstrate potential sex-specific profiles among schizophrenia cases with hypovitaminosis.

Original languageEnglish (US)
Pages (from-to)543-545
Number of pages3
JournalSchizophrenia Research
Volume159
Issue number2-3
DOIs
StatePublished - Nov 1 2014

Fingerprint

Vitamin D
Schizophrenia
Telomere
Leukocytes
Cell Aging
Anhedonia
Social Adjustment
Hallucinations
Poverty
Aggression
Cognition
Polymerase Chain Reaction

Keywords

  • Aggression
  • Hypovitaminosis D
  • Negative symptoms
  • Schizophrenia
  • Telomere length
  • Vitamin D

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Cieslak, K., Feingold, J., Antonius, D., Walsh-Messinger, J., Dracxler, R., Rosedale, M., ... Malaspina, D. (2014). Low Vitamin D levels predict clinical features of schizophrenia. Schizophrenia Research, 159(2-3), 543-545. https://doi.org/10.1016/j.schres.2014.08.031

Low Vitamin D levels predict clinical features of schizophrenia. / Cieslak, Kristina; Feingold, Jordyn; Antonius, Daniel; Walsh-Messinger, Julie; Dracxler, Roberta; Rosedale, Mary; Aujero, Nicole; Keefe, David; Goetz, Deborah; Goetz, Raymond; Malaspina, Dolores.

In: Schizophrenia Research, Vol. 159, No. 2-3, 01.11.2014, p. 543-545.

Research output: Contribution to journalArticle

Cieslak, K, Feingold, J, Antonius, D, Walsh-Messinger, J, Dracxler, R, Rosedale, M, Aujero, N, Keefe, D, Goetz, D, Goetz, R & Malaspina, D 2014, 'Low Vitamin D levels predict clinical features of schizophrenia', Schizophrenia Research, vol. 159, no. 2-3, pp. 543-545. https://doi.org/10.1016/j.schres.2014.08.031
Cieslak K, Feingold J, Antonius D, Walsh-Messinger J, Dracxler R, Rosedale M et al. Low Vitamin D levels predict clinical features of schizophrenia. Schizophrenia Research. 2014 Nov 1;159(2-3):543-545. https://doi.org/10.1016/j.schres.2014.08.031
Cieslak, Kristina ; Feingold, Jordyn ; Antonius, Daniel ; Walsh-Messinger, Julie ; Dracxler, Roberta ; Rosedale, Mary ; Aujero, Nicole ; Keefe, David ; Goetz, Deborah ; Goetz, Raymond ; Malaspina, Dolores. / Low Vitamin D levels predict clinical features of schizophrenia. In: Schizophrenia Research. 2014 ; Vol. 159, No. 2-3. pp. 543-545.
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