Low-power suppression of fast-motion spin 3/2 signals

Evgeny Nimerovsky, Andrew J. Ilott, Alexej Jerschow

Research output: Contribution to journalArticle

Abstract

Triple Quantum Filters (TQFs) are frequently used for the selection of bi-exponentially relaxing spin 3/2 nuclei (in particular 23Na) in ordered environments, such as biological tissues. These methods provide an excellent selection of slow-motion spins, but their sensitivity is generally low, and coherence selection requirements may lead to long experiments when applied in vivo. Alternative methods, such as 2P DIM, have demonstrated that the sensitivities of the signals from bi-exponentially relaxing sodium can be significantly increased using strategies other than TQFs. A shortcoming of the 2P DIM method is its strong dependence on B0 inhomogeneities. We describe here a method, which is sensitive to the slow-motion regime, while the signal from spins in the fast-motion regime is suppressed. This method is shown to be more effective than TQFs, requires minimal phase cycling for the suppression of the influence of rf inhomogeneity, and has less dependence on resonance offsets and B0-inhomogeneity than 2P DIM.

Original languageEnglish (US)
Pages (from-to)129-140
Number of pages12
JournalJournal of Magnetic Resonance
Volume272
DOIs
StatePublished - Nov 1 2016

Fingerprint

inhomogeneity
Sodium
retarding
Tissue
filters
Experiments
sensitivity
sodium
requirements
cycles
nuclei

Keywords

  • Bi-exponential relaxation
  • Slow-motion sodium
  • Sodium NMR
  • Weak radio-frequency fields

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

Cite this

Low-power suppression of fast-motion spin 3/2 signals. / Nimerovsky, Evgeny; Ilott, Andrew J.; Jerschow, Alexej.

In: Journal of Magnetic Resonance, Vol. 272, 01.11.2016, p. 129-140.

Research output: Contribution to journalArticle

Nimerovsky, Evgeny ; Ilott, Andrew J. ; Jerschow, Alexej. / Low-power suppression of fast-motion spin 3/2 signals. In: Journal of Magnetic Resonance. 2016 ; Vol. 272. pp. 129-140.
@article{7dd846369a924b129b98cc23d8563641,
title = "Low-power suppression of fast-motion spin 3/2 signals",
abstract = "Triple Quantum Filters (TQFs) are frequently used for the selection of bi-exponentially relaxing spin 3/2 nuclei (in particular 23Na) in ordered environments, such as biological tissues. These methods provide an excellent selection of slow-motion spins, but their sensitivity is generally low, and coherence selection requirements may lead to long experiments when applied in vivo. Alternative methods, such as 2P DIM, have demonstrated that the sensitivities of the signals from bi-exponentially relaxing sodium can be significantly increased using strategies other than TQFs. A shortcoming of the 2P DIM method is its strong dependence on B0 inhomogeneities. We describe here a method, which is sensitive to the slow-motion regime, while the signal from spins in the fast-motion regime is suppressed. This method is shown to be more effective than TQFs, requires minimal phase cycling for the suppression of the influence of rf inhomogeneity, and has less dependence on resonance offsets and B0-inhomogeneity than 2P DIM.",
keywords = "Bi-exponential relaxation, Slow-motion sodium, Sodium NMR, Weak radio-frequency fields",
author = "Evgeny Nimerovsky and Ilott, {Andrew J.} and Alexej Jerschow",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.jmr.2016.09.007",
language = "English (US)",
volume = "272",
pages = "129--140",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Low-power suppression of fast-motion spin 3/2 signals

AU - Nimerovsky, Evgeny

AU - Ilott, Andrew J.

AU - Jerschow, Alexej

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Triple Quantum Filters (TQFs) are frequently used for the selection of bi-exponentially relaxing spin 3/2 nuclei (in particular 23Na) in ordered environments, such as biological tissues. These methods provide an excellent selection of slow-motion spins, but their sensitivity is generally low, and coherence selection requirements may lead to long experiments when applied in vivo. Alternative methods, such as 2P DIM, have demonstrated that the sensitivities of the signals from bi-exponentially relaxing sodium can be significantly increased using strategies other than TQFs. A shortcoming of the 2P DIM method is its strong dependence on B0 inhomogeneities. We describe here a method, which is sensitive to the slow-motion regime, while the signal from spins in the fast-motion regime is suppressed. This method is shown to be more effective than TQFs, requires minimal phase cycling for the suppression of the influence of rf inhomogeneity, and has less dependence on resonance offsets and B0-inhomogeneity than 2P DIM.

AB - Triple Quantum Filters (TQFs) are frequently used for the selection of bi-exponentially relaxing spin 3/2 nuclei (in particular 23Na) in ordered environments, such as biological tissues. These methods provide an excellent selection of slow-motion spins, but their sensitivity is generally low, and coherence selection requirements may lead to long experiments when applied in vivo. Alternative methods, such as 2P DIM, have demonstrated that the sensitivities of the signals from bi-exponentially relaxing sodium can be significantly increased using strategies other than TQFs. A shortcoming of the 2P DIM method is its strong dependence on B0 inhomogeneities. We describe here a method, which is sensitive to the slow-motion regime, while the signal from spins in the fast-motion regime is suppressed. This method is shown to be more effective than TQFs, requires minimal phase cycling for the suppression of the influence of rf inhomogeneity, and has less dependence on resonance offsets and B0-inhomogeneity than 2P DIM.

KW - Bi-exponential relaxation

KW - Slow-motion sodium

KW - Sodium NMR

KW - Weak radio-frequency fields

UR - http://www.scopus.com/inward/record.url?scp=84988876270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988876270&partnerID=8YFLogxK

U2 - 10.1016/j.jmr.2016.09.007

DO - 10.1016/j.jmr.2016.09.007

M3 - Article

VL - 272

SP - 129

EP - 140

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

ER -