Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients

Abdishakur Abdulle, Michael P.T. Gillett, Samra Abouchacra, Sufyan M. Sabri, Mona Al Rukhaimi, Enyioma N. Obineche, Jaipaul Singh

    Research output: Contribution to journalArticle

    Abstract

    Cardiovascular diseases (CVD) constitute a significant risk and may, in part, explain the high morbidity and mortality rates among haemodialysis (HD) patients. Several studies have implicated reduced insulin like growth factor (IGF-1) levels in the development of CVD. However, it is not clear whether IGF-1, and its relationship with other hormones such as leptin, insulin, and growth hormone (GH), as well as anthropometric variables may explain the high incidence of vascular complications in chronic kidney disease (CKD) patients. This study was designed to measure total serum IGF-1, leptin, insulin and GH levels in CKD patients and in age-matched control subjects and to elucidate the relationship between IGF-1 and GH, leptin, and insulin as well as other known aetiological risk factors for CVD including blood pressure, body mass index (BMI), and age. The study consisted of 50 CKD patients [36 M and 14 F; mean age; 41.8 ± 10.3 years) on maintenance haemodialysis and 50 healthy control subjects (36 M and 14 F; mean age 41.6 ± 10.2 years) matched for age and sex. None of the subject among patients and controls reported either smoking or history of diabetes mellitus. The circulating levels of IGF-1 were significantly lower (P < 0.001) in both male and female patients compared to the control subjects. Moreover, IGF-1 was strongly and inversely correlated with both systolic blood pressure (SBP) (r = -0.360; P < 0.01) and diastolic blood pressure (DBP) (r = -0.512; P < 0.001) in the CKD group, and when the two groups were combined SBP (r = -0.396; P < 0.001) and DBP (r = -0.296; P < 0.01). When adjusted for age, the correlation was more significant, however, when adjusted for BMI no significant correlation was observed between IGF-1 and blood pressure. IGF-1 was inversely correlated with age (r = -0.367; P < 0.01) and BMI (r = -0.310; P < 0.05) in the control group, but not the patient group. In controls and patients, respectively, a positive correlation between leptin and BMI (r = 0.358; P < 0.01; r = 0.640, P < 0.001) was observed. The results show that circulating levels of IGF-1 were significantly lower in CKD patients as compared to healthy normal subjects and were inversely correlated with SBP and DBP independent of age, but not BMI indicative of a strong relationship between cardiovascular risk factors and low IGF-1 levels. Although, the data do not clearly indicate low IGF-1 levels as a cause or an effect of these cardiovascular risk factors, they do point to an interesting relationship between low IGF-1 levels and increased cardiovascular risk factors among CKD patients as compared to age-matched healthy control subjects.

    Original languageEnglish (US)
    Pages (from-to)195-201
    Number of pages7
    JournalMolecular and Cellular Biochemistry
    Volume302
    Issue number1-2
    DOIs
    StatePublished - Aug 1 2007

    Fingerprint

    Insulin-Like Growth Factor I
    Renal Dialysis
    Blood pressure
    Blood Pressure
    Chronic Renal Insufficiency
    Leptin
    Body Mass Index
    Growth Hormone
    Healthy Volunteers
    Insulin
    Cardiovascular Diseases
    Somatomedins
    Medical problems
    Blood Vessels
    Diabetes Mellitus
    Hormones
    Smoking
    Maintenance

    Keywords

    • Blood pressure
    • Cardiovascular risk factors
    • Chronic kidney disease
    • IGF-1
    • Insulin like growth factor-1
    • United Arab Emirates

    ASJC Scopus subject areas

    • Molecular Biology
    • Clinical Biochemistry
    • Cell Biology

    Cite this

    Abdulle, A., Gillett, M. P. T., Abouchacra, S., Sabri, S. M., Rukhaimi, M. A., Obineche, E. N., & Singh, J. (2007). Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients. Molecular and Cellular Biochemistry, 302(1-2), 195-201. https://doi.org/10.1007/s11010-007-9441-6

    Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients. / Abdulle, Abdishakur; Gillett, Michael P.T.; Abouchacra, Samra; Sabri, Sufyan M.; Rukhaimi, Mona Al; Obineche, Enyioma N.; Singh, Jaipaul.

    In: Molecular and Cellular Biochemistry, Vol. 302, No. 1-2, 01.08.2007, p. 195-201.

    Research output: Contribution to journalArticle

    Abdulle, A, Gillett, MPT, Abouchacra, S, Sabri, SM, Rukhaimi, MA, Obineche, EN & Singh, J 2007, 'Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients', Molecular and Cellular Biochemistry, vol. 302, no. 1-2, pp. 195-201. https://doi.org/10.1007/s11010-007-9441-6
    Abdulle A, Gillett MPT, Abouchacra S, Sabri SM, Rukhaimi MA, Obineche EN et al. Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients. Molecular and Cellular Biochemistry. 2007 Aug 1;302(1-2):195-201. https://doi.org/10.1007/s11010-007-9441-6
    Abdulle, Abdishakur ; Gillett, Michael P.T. ; Abouchacra, Samra ; Sabri, Sufyan M. ; Rukhaimi, Mona Al ; Obineche, Enyioma N. ; Singh, Jaipaul. / Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients. In: Molecular and Cellular Biochemistry. 2007 ; Vol. 302, No. 1-2. pp. 195-201.
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    AU - Sabri, Sufyan M.

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