Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment

Anuja Sharma, Stanley Durrleman, John H. Gilmore, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We present a new framework for spatiotemporal analysis of parameterized functions attributed by properties of 4D longitudinal image data. Our driving application is the measurement of temporal change in white matter diffusivity of fiber tracts. A smooth temporal modeling of change from a discrete-time set of functions is obtained with an extension of the logistic growth model to time-dependent spline functions, capturing growth with only a few descriptive parameters. An unbiased template baseline function is also jointly estimated. Solution is demonstrated via energy minimization with an extension to simultaneous modeling of trajectories for multiple subjects. The new framework is validated with synthetic data and applied to longitudinal DTI from 15 infants. Interpretation of estimated model growth parameters is facilitated by visualization in the original coordinate space of fiber tracts.

    Original languageEnglish (US)
    Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings
    Pages1397-1400
    Number of pages4
    DOIs
    StatePublished - 2012
    Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
    Duration: May 2 2012May 5 2012

    Other

    Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
    CountrySpain
    CityBarcelona
    Period5/2/125/5/12

    Fingerprint

    Growth
    Spatio-Temporal Analysis
    Fibers
    Splines
    Logistics
    Visualization
    Logistic Models
    Trajectories
    White Matter

    Keywords

    • diffusion tensor imaging
    • early brain developming
    • growth functions
    • longitudinal image data
    • spatiotemporal modeling

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

    Cite this

    Sharma, A., Durrleman, S., Gilmore, J. H., & Gerig, G. (2012). Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings (pp. 1397-1400). [6235829] https://doi.org/10.1109/ISBI.2012.6235829

    Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment. / Sharma, Anuja; Durrleman, Stanley; Gilmore, John H.; Gerig, Guido.

    2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings. 2012. p. 1397-1400 6235829.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Sharma, A, Durrleman, S, Gilmore, JH & Gerig, G 2012, Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment. in 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings., 6235829, pp. 1397-1400, 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012, Barcelona, Spain, 5/2/12. https://doi.org/10.1109/ISBI.2012.6235829
    Sharma A, Durrleman S, Gilmore JH, Gerig G. Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings. 2012. p. 1397-1400. 6235829 https://doi.org/10.1109/ISBI.2012.6235829
    Sharma, Anuja ; Durrleman, Stanley ; Gilmore, John H. ; Gerig, Guido. / Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment. 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings. 2012. pp. 1397-1400
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