Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls

Andrea Deierlein, Mary S. Wolff, Ashley Pajak, Susan M. Pinney, Gayle C. Windham, Maida P. Galvez, Manori J. Silva, Antonia M. Calafat, Lawrence H. Kushi, Frank M. Biro, Susan L. Teitelbaum

Research output: Contribution to journalArticle

Abstract

Background: Phthalates are environmental chemicals that may play a role in the development of obesity. Few studies have investigated longitudinal associations between postnatal phthalate exposures and subsequent anthropometric measurements in children. Methods: We collected data as part of The Breast Cancer and Environment Research Program at three US sites. A total of 1,239 girls, aged 6-8 years, were enrolled in 2004-2007. We categorized baseline phthalate exposures, assessed from creatinine-corrected urinary concentrations of low-molecular weight phthalate metabolites, as low, 2 (95% CI: 0.28, 2.1) and from 1.5 (95% CI: -0.38, 3.3) to 3.9 cm (95% CI: 1.3, 6.5), respectively. High-molecular weight phthalates were negatively associated with height but only among girls who were normal weight at baseline (BMI ≤ 85th percentile). Conclusion: Phthalates, specifically low-molecular weight phthalates, have small but detectable associations with girls' anthropometric outcomes. Low-molecular weight phthalates showed stronger associations than other types of phthalates.

Original languageEnglish (US)
Pages (from-to)492-499
Number of pages8
JournalEpidemiology
Volume27
Issue number4
DOIs
StatePublished - Jul 1 2016

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Body Size
Molecular Weight
phthalic acid
Creatinine
Obesity
Breast Neoplasms
Weights and Measures
Research

ASJC Scopus subject areas

  • Epidemiology

Cite this

Deierlein, A., Wolff, M. S., Pajak, A., Pinney, S. M., Windham, G. C., Galvez, M. P., ... Teitelbaum, S. L. (2016). Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls. Epidemiology, 27(4), 492-499. https://doi.org/10.1097/EDE.0000000000000489

Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls. / Deierlein, Andrea; Wolff, Mary S.; Pajak, Ashley; Pinney, Susan M.; Windham, Gayle C.; Galvez, Maida P.; Silva, Manori J.; Calafat, Antonia M.; Kushi, Lawrence H.; Biro, Frank M.; Teitelbaum, Susan L.

In: Epidemiology, Vol. 27, No. 4, 01.07.2016, p. 492-499.

Research output: Contribution to journalArticle

Deierlein, A, Wolff, MS, Pajak, A, Pinney, SM, Windham, GC, Galvez, MP, Silva, MJ, Calafat, AM, Kushi, LH, Biro, FM & Teitelbaum, SL 2016, 'Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls', Epidemiology, vol. 27, no. 4, pp. 492-499. https://doi.org/10.1097/EDE.0000000000000489
Deierlein, Andrea ; Wolff, Mary S. ; Pajak, Ashley ; Pinney, Susan M. ; Windham, Gayle C. ; Galvez, Maida P. ; Silva, Manori J. ; Calafat, Antonia M. ; Kushi, Lawrence H. ; Biro, Frank M. ; Teitelbaum, Susan L. / Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls. In: Epidemiology. 2016 ; Vol. 27, No. 4. pp. 492-499.
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