Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

A. Rullo, A. Reiner, A. Reiter, Dirk Trauner, E. Y. Isacoff, G. A. Woolley

Research output: Contribution to journalArticle

Abstract

A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

Original languageEnglish (US)
Pages (from-to)14613-14615
Number of pages3
JournalChemical Communications
Volume50
Issue number93
DOIs
StatePublished - Dec 4 2014

Fingerprint

Azobenzene
Glutamate Receptors
Ion Channels
Derivatives
Ionotropic Glutamate Receptors
Wavelength
Ions
Scaffolds
Ligands
Proteins
azobenzene

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative. / Rullo, A.; Reiner, A.; Reiter, A.; Trauner, Dirk; Isacoff, E. Y.; Woolley, G. A.

In: Chemical Communications, Vol. 50, No. 93, 04.12.2014, p. 14613-14615.

Research output: Contribution to journalArticle

Rullo, A. ; Reiner, A. ; Reiter, A. ; Trauner, Dirk ; Isacoff, E. Y. ; Woolley, G. A. / Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative. In: Chemical Communications. 2014 ; Vol. 50, No. 93. pp. 14613-14615.
@article{44bc4b6d072847fd99c9865db2613918,
title = "Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative",
abstract = "A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.",
author = "A. Rullo and A. Reiner and A. Reiter and Dirk Trauner and Isacoff, {E. Y.} and Woolley, {G. A.}",
year = "2014",
month = "12",
day = "4",
doi = "10.1039/c4cc06612j",
language = "English (US)",
volume = "50",
pages = "14613--14615",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "93",

}

TY - JOUR

T1 - Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

AU - Rullo, A.

AU - Reiner, A.

AU - Reiter, A.

AU - Trauner, Dirk

AU - Isacoff, E. Y.

AU - Woolley, G. A.

PY - 2014/12/4

Y1 - 2014/12/4

N2 - A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

AB - A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

UR - http://www.scopus.com/inward/record.url?scp=84908701428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908701428&partnerID=8YFLogxK

U2 - 10.1039/c4cc06612j

DO - 10.1039/c4cc06612j

M3 - Article

VL - 50

SP - 14613

EP - 14615

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 93

ER -