Long-term outcomes of 3D-printed bioactive ceramic scaffolds for regeneration of the pediatric skeleton

M. M. Wang, R. Rodriguez Colon, G. D. Kurgansky, Lukasz Witek, A. Torroni, B. N. Cronstein, R. L. Flores, Paulo Coelho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Our group has previously demonstrated the efficacy of 3D printed Bioceramic (3DPBC) scaffolds in the reconstruction of critically-sized craniofacial defects in adult [1] and pediatric animal models. These regenerative technologies may overcome existing challenges of alloplastic reconstruction or autogenous bone graft, the standard of care for pediatric craniofacial reconstruction. Additionally, we have demonstrated that dipyridamole (DIPY) treated scaffolds significantly augment bone regeneration without causing premature cranial suture fusion or malignant degeneration [1], negative effects which have been associated with morphogenic protein 2 (BMP-2). a commonly-used commercial osteogenic agent[2]. In this pediatric animal model, we seek to quantify long-term bone regeneration and scaffold degradation kinetics, and further investigate the safety of 3DPBC scaffolds in vivo including their effects on suture patency and facial development.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Wang, M. M., Rodriguez Colon, R., Kurgansky, G. D., Witek, L., Torroni, A., Cronstein, B. N., Flores, R. L., & Coelho, P. (2019). Long-term outcomes of 3D-printed bioactive ceramic scaffolds for regeneration of the pediatric skeleton. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.