Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers

V. Saxena, M. Sadoqi, S. Kumar, J. Shao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Indocyanine green (ICG) is a near-infrared fluorescence contrast agent, which has enormous potential in early tumor diagnosis and therapy. The objective of this study is to develop biodegradable nanoparticles entrapping ICG and to characterize its intracellular uptake and photodynamic activity in different cancer cell lines. Nanoparticles entrapping ICG were engineered, characterized and the intracellular uptake of ICG was investigated in B16-F10 and C-33A cancer cell lines. The photodynamic activity of ICG-loaded nanoparticles was also investigated. The nanoparticles enhanced the intracellular uptake of ICG and showed significant photodynamic activity, especially at very low ICG concentrations. These preliminary studies indicate the potential of efficient tumor cell delivery and tumoricidal effect of ICG when incorporated in nanoparticles.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsK.E. Bartels, L.S. Bass, W.T.W. Riese, K.W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S.J. Madsen, R.S. Malek
Pages41-46
Number of pages6
Volume5
Edition1
DOIs
StatePublished - 2004
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV - San Jose, CA, United States
Duration: Jan 24 2004Jan 27 2004

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
CountryUnited States
CitySan Jose, CA
Period1/24/041/27/04

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Keywords

  • Fluorescence
  • Indocyanine green
  • Intracellular uptake
  • Nanoparticles
  • Photodynamic therapy
  • PLGA

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Saxena, V., Sadoqi, M., Kumar, S., & Shao, J. (2004). Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers. In K. E. Bartels, L. S. Bass, W. T. W. Riese, K. W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S. J. Madsen, & R. S. Malek (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (1 ed., Vol. 5, pp. 41-46). [09] https://doi.org/10.1117/12.534336