Lock and key colloids

S. Sacanna, W. T M Irvine, P. M. Chaikin, D. J. Pine

Research output: Contribution to journalArticle

Abstract

New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching programmed DNA strands to nanometre-and micrometre-sized particles and then using DNA hybridization to direct the placement of the particles in the final assembly. Here we demonstrate an alternative recognition mechanism for directing the assembly of composite structures, based on particles with complementary shapes. Our system, which uses Fischers lock-and-key principle, employs colloidal spheres as keys and monodisperse colloidal particles with a spherical cavity as locks that bind spontaneously and reversibly via the depletion interaction. The lock-and-key binding is specific because it is controlled by how closely the size of a spherical colloidal key particle matches the radius of the spherical cavity of the lock particle. The strength of the binding can be further tuned by adjusting the solution composition or temperature. The composite assemblies have the unique feature of having flexible bonds, allowing us to produce flexible dimeric, trimeric and tetrameric colloidal molecules as well as more complex colloidal polymers. We expect that this lock-and-key recognition mechanism will find wider use as a means of programming and directing colloidal self-assembly.

Original languageEnglish (US)
Pages (from-to)575-578
Number of pages4
JournalNature
Volume464
Issue number7288
DOIs
StatePublished - Mar 25 2010

Fingerprint

Colloids
DNA
Polymers
Temperature

ASJC Scopus subject areas

  • General

Cite this

Sacanna, S., Irvine, W. T. M., Chaikin, P. M., & Pine, D. J. (2010). Lock and key colloids. Nature, 464(7288), 575-578. https://doi.org/10.1038/nature08906

Lock and key colloids. / Sacanna, S.; Irvine, W. T M; Chaikin, P. M.; Pine, D. J.

In: Nature, Vol. 464, No. 7288, 25.03.2010, p. 575-578.

Research output: Contribution to journalArticle

Sacanna, S, Irvine, WTM, Chaikin, PM & Pine, DJ 2010, 'Lock and key colloids', Nature, vol. 464, no. 7288, pp. 575-578. https://doi.org/10.1038/nature08906
Sacanna S, Irvine WTM, Chaikin PM, Pine DJ. Lock and key colloids. Nature. 2010 Mar 25;464(7288):575-578. https://doi.org/10.1038/nature08906
Sacanna, S. ; Irvine, W. T M ; Chaikin, P. M. ; Pine, D. J. / Lock and key colloids. In: Nature. 2010 ; Vol. 464, No. 7288. pp. 575-578.
@article{dc1f72c94f774fd086748bfe56916663,
title = "Lock and key colloids",
abstract = "New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching programmed DNA strands to nanometre-and micrometre-sized particles and then using DNA hybridization to direct the placement of the particles in the final assembly. Here we demonstrate an alternative recognition mechanism for directing the assembly of composite structures, based on particles with complementary shapes. Our system, which uses Fischers lock-and-key principle, employs colloidal spheres as keys and monodisperse colloidal particles with a spherical cavity as locks that bind spontaneously and reversibly via the depletion interaction. The lock-and-key binding is specific because it is controlled by how closely the size of a spherical colloidal key particle matches the radius of the spherical cavity of the lock particle. The strength of the binding can be further tuned by adjusting the solution composition or temperature. The composite assemblies have the unique feature of having flexible bonds, allowing us to produce flexible dimeric, trimeric and tetrameric colloidal molecules as well as more complex colloidal polymers. We expect that this lock-and-key recognition mechanism will find wider use as a means of programming and directing colloidal self-assembly.",
author = "S. Sacanna and Irvine, {W. T M} and Chaikin, {P. M.} and Pine, {D. J.}",
year = "2010",
month = "3",
day = "25",
doi = "10.1038/nature08906",
language = "English (US)",
volume = "464",
pages = "575--578",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7288",

}

TY - JOUR

T1 - Lock and key colloids

AU - Sacanna, S.

AU - Irvine, W. T M

AU - Chaikin, P. M.

AU - Pine, D. J.

PY - 2010/3/25

Y1 - 2010/3/25

N2 - New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching programmed DNA strands to nanometre-and micrometre-sized particles and then using DNA hybridization to direct the placement of the particles in the final assembly. Here we demonstrate an alternative recognition mechanism for directing the assembly of composite structures, based on particles with complementary shapes. Our system, which uses Fischers lock-and-key principle, employs colloidal spheres as keys and monodisperse colloidal particles with a spherical cavity as locks that bind spontaneously and reversibly via the depletion interaction. The lock-and-key binding is specific because it is controlled by how closely the size of a spherical colloidal key particle matches the radius of the spherical cavity of the lock particle. The strength of the binding can be further tuned by adjusting the solution composition or temperature. The composite assemblies have the unique feature of having flexible bonds, allowing us to produce flexible dimeric, trimeric and tetrameric colloidal molecules as well as more complex colloidal polymers. We expect that this lock-and-key recognition mechanism will find wider use as a means of programming and directing colloidal self-assembly.

AB - New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching programmed DNA strands to nanometre-and micrometre-sized particles and then using DNA hybridization to direct the placement of the particles in the final assembly. Here we demonstrate an alternative recognition mechanism for directing the assembly of composite structures, based on particles with complementary shapes. Our system, which uses Fischers lock-and-key principle, employs colloidal spheres as keys and monodisperse colloidal particles with a spherical cavity as locks that bind spontaneously and reversibly via the depletion interaction. The lock-and-key binding is specific because it is controlled by how closely the size of a spherical colloidal key particle matches the radius of the spherical cavity of the lock particle. The strength of the binding can be further tuned by adjusting the solution composition or temperature. The composite assemblies have the unique feature of having flexible bonds, allowing us to produce flexible dimeric, trimeric and tetrameric colloidal molecules as well as more complex colloidal polymers. We expect that this lock-and-key recognition mechanism will find wider use as a means of programming and directing colloidal self-assembly.

UR - http://www.scopus.com/inward/record.url?scp=77950219326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950219326&partnerID=8YFLogxK

U2 - 10.1038/nature08906

DO - 10.1038/nature08906

M3 - Article

VL - 464

SP - 575

EP - 578

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7288

ER -