Localized differences in caudate and hippocampal shape are associated with schizophrenia but not antipsychotic type

Robert K. McClure, Martin Styner, Eric Maltbie, Jeffrey A. Lieberman, Sylvain Gouttard, Guido Gerig, Xiaoyan Shi, Hongtu Zhu

    Research output: Contribution to journalArticle

    Abstract

    Caudate and hippocampal volume differences in patients with schizophrenia are associated with disease and antipsychotic treatment, but local shape alterations have not been thoroughly examined. Schizophrenia patients randomly assigned to haloperidol and olanzapine treatment underwent magnetic resonance imaging (MRI) at 3, 6, and 12 months. The caudate and hippocampus were represented as medial representations (M-reps); mesh structures derived from automatic segmentations of high resolution MRIs. Two quantitative shape measures were examined: local width and local deformation. A novel nonparametric statistical method, adjusted exponentially tilted (ET) likelihood, was used to compare the shape measures across the three groups while controlling for covariates. Longitudinal shape change was not observed in the hippocampus or caudate when the treatment groups and controls were examined in a global analysis, nor when the three groups were examined individually. Both baseline and repeated measures analysis showed differences in local caudate and hippocampal size between patients and controls, while no consistent differences were shown between treatment groups. Regionally specific differences in local hippocampal and caudate shape are present in schizophrenic patients. Treatment-related related longitudinal shape change was not observed within the studied timeframe. Our results provide additional evidence for disrupted cortico-basal ganglia-thalamo-cortical circuits in schizophrenia. Clinical trial information: This longitudinal study was conducted from March 1, 1997 to July 31, 2001 at 14 academic medical centers (11 in the United States, one in Canada, one in the Netherlands, and one in England). This study was performed prior to the establishment of centralized registries of federally and privately supported clinical trials.

    Original languageEnglish (US)
    Pages (from-to)1-10
    Number of pages10
    JournalPsychiatry Research - Neuroimaging
    Volume211
    Issue number1
    DOIs
    StatePublished - Jan 30 2013

    Fingerprint

    Antipsychotic Agents
    Schizophrenia
    olanzapine
    Hippocampus
    Clinical Trials
    Therapeutics
    Haloperidol
    Basal Ganglia
    England
    Netherlands
    Canada
    Longitudinal Studies
    Registries
    Magnetic Resonance Imaging
    Control Groups

    Keywords

    • Antipsychotic
    • Caudate
    • Hippocampus
    • Morphometry
    • MRI
    • Schizophrenia

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Radiology Nuclear Medicine and imaging
    • Neuroscience (miscellaneous)

    Cite this

    Localized differences in caudate and hippocampal shape are associated with schizophrenia but not antipsychotic type. / McClure, Robert K.; Styner, Martin; Maltbie, Eric; Lieberman, Jeffrey A.; Gouttard, Sylvain; Gerig, Guido; Shi, Xiaoyan; Zhu, Hongtu.

    In: Psychiatry Research - Neuroimaging, Vol. 211, No. 1, 30.01.2013, p. 1-10.

    Research output: Contribution to journalArticle

    McClure, Robert K. ; Styner, Martin ; Maltbie, Eric ; Lieberman, Jeffrey A. ; Gouttard, Sylvain ; Gerig, Guido ; Shi, Xiaoyan ; Zhu, Hongtu. / Localized differences in caudate and hippocampal shape are associated with schizophrenia but not antipsychotic type. In: Psychiatry Research - Neuroimaging. 2013 ; Vol. 211, No. 1. pp. 1-10.
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