Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing

Christopher D. Lopez, Jonathan M. Bekisz, Carmen Corciulo, Aranzazu Mediero, Paulo Coelho, Lukasz Witek, Roberto L. Flores, Bruce N. Cronstein

Research output: Contribution to journalArticle

Abstract

Adenosine receptor activation has been investigated as a potential therapeutic approach to heal bone. Bone has enhanced regenerative potential when influenced by either direct or indirect adenosine receptor agonism. As investigators continue to elucidate how adenosine influences bone cell homeostasis at the cellular and molecular levels, a small but growing body of literature has reported successful in vivo applications of adenosine delivery. This review summarizes the role adenosine receptor ligation plays in osteoblast and osteoclast biology and remodeling/regeneration. It also reports on all the modalities described in the literature at this point for delivery of adenosine through in vivo models for bone healing and regeneration.

Original languageEnglish (US)
JournalAdvanced Drug Delivery Reviews
DOIs
StateAccepted/In press - Jan 1 2018

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Purinergic P1 Receptor Agonists
Bone Regeneration
Purinergic P1 Receptors
Adenosine
Bone and Bones
Osteoclasts
Osteoblasts
Ligation
Regeneration
Homeostasis
Research Personnel
Therapeutics

Keywords

  • Adenosine receptor
  • Bone regeneration
  • Osteoblast
  • Osteoclast
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing. / Lopez, Christopher D.; Bekisz, Jonathan M.; Corciulo, Carmen; Mediero, Aranzazu; Coelho, Paulo; Witek, Lukasz; Flores, Roberto L.; Cronstein, Bruce N.

In: Advanced Drug Delivery Reviews, 01.01.2018.

Research output: Contribution to journalArticle

Lopez, Christopher D. ; Bekisz, Jonathan M. ; Corciulo, Carmen ; Mediero, Aranzazu ; Coelho, Paulo ; Witek, Lukasz ; Flores, Roberto L. ; Cronstein, Bruce N. / Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing. In: Advanced Drug Delivery Reviews. 2018.
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