Local adaptation and vector-mediated population structure in Plasmodium vivax malaria

Deirdre A. Joy, Lilia Gonzalez-Ceron, Jane M. Carlton, Amy Gueye, Michael Fay, Thomas F. McCutchan, Xin Zhuan Su

Research output: Contribution to journalArticle

Abstract

Plasmodium vivax in southern Mexico exhibits different infectivities to 2 local mosquito vectors, Anopheles pseudopunctipennis and Anopheles albimanus. Previous work has tied these differences in mosquito infectivity to variation in the central repeat motif of the malaria parasite's circumsporozoite (csp) gene, but subsequent studies have questioned this view. Here we present evidence that P. vivax in southern Mexico comprised 3 genetic populations whose distributions largely mirror those of the 2 mosquito vectors. Additionally, laboratory colony feeding experiments indicate that parasite populations are most compatible with sympatric mosquito species. Our results suggest that reciprocal selection between malaria parasites and mosquito vectors has led to local adaptation of the parasite. Adaptation to local vectors may play an important role in generating population structure in Plasmodium. A better understanding of coevolutionary dynamics between sympatric mosquitoes and parasites will facilitate the identification of molecular mechanisms relevant to disease transmission in nature and provide crucial information for malaria control.

Original languageEnglish (US)
Pages (from-to)1245-1252
Number of pages8
JournalMolecular Biology and Evolution
Volume25
Issue number6
DOIs
StatePublished - Jun 2008

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Vivax Malaria
Plasmodium vivax
local adaptation
malaria
mosquito
population structure
Culicidae
Parasites
parasite
Malaria
parasites
Anopheles
Population
Mexico
infectivity
Malaria control
Sympatry
Population distribution
Anopheles pseudopunctipennis
pathogenicity

Keywords

  • Coevolution
  • Malaria
  • Microsatellites
  • Plasmodium vivax

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Local adaptation and vector-mediated population structure in Plasmodium vivax malaria. / Joy, Deirdre A.; Gonzalez-Ceron, Lilia; Carlton, Jane M.; Gueye, Amy; Fay, Michael; McCutchan, Thomas F.; Su, Xin Zhuan.

In: Molecular Biology and Evolution, Vol. 25, No. 6, 06.2008, p. 1245-1252.

Research output: Contribution to journalArticle

Joy, DA, Gonzalez-Ceron, L, Carlton, JM, Gueye, A, Fay, M, McCutchan, TF & Su, XZ 2008, 'Local adaptation and vector-mediated population structure in Plasmodium vivax malaria', Molecular Biology and Evolution, vol. 25, no. 6, pp. 1245-1252. https://doi.org/10.1093/molbev/msn073
Joy, Deirdre A. ; Gonzalez-Ceron, Lilia ; Carlton, Jane M. ; Gueye, Amy ; Fay, Michael ; McCutchan, Thomas F. ; Su, Xin Zhuan. / Local adaptation and vector-mediated population structure in Plasmodium vivax malaria. In: Molecular Biology and Evolution. 2008 ; Vol. 25, No. 6. pp. 1245-1252.
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