Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors

Pierre Flandin, Yangu Zhao, Daniel Vogt, Juhee Jeong, Jason Long, Gregory Potter, Heiner Westphal, John L R Rubenstein

Research output: Contribution to journalArticle

Abstract

Lhx6 and Lhx8 transcription factor coexpression in early-born MGE neurons is required to induce neuronal Shh expression. We provide evidence that these transcription factors regulate expression of a Shh enhancer in MGE neurons. Lhx6 and Lhx8 are also required to prevent Nkx2-1 expression in a subset of pallial interneurons. Shh function in early-born MGE neurons was determined by genetically eliminating Shh expression in the MGE mantle zone (MZ). This mutant had reduced SHH signaling in the overlying progenitor zone, which led to reduced Lhx6, Lhx8, and Nkx2-1 expression in the rostrodorsal MGE and a preferential reduction of late-born somatostatin+ and parvalbumin+ cortical interneurons. Thus, Lhx6 and Lhx8 regulate MGE development through autonomous and nonautonomous mechanisms, the latter by promoting Shh expression in MGE neurons, which in turn feeds forward to promote the developmental program of the rostrodorsal MGE.

Original languageEnglish (US)
Pages (from-to)939-950
Number of pages12
JournalNeuron
Volume70
Issue number5
DOIs
StatePublished - Jun 9 2011

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Interneurons
Neurons
Transcription Factors
Parvalbumins
Somatostatin

ASJC Scopus subject areas

  • Neuroscience(all)

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Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors. / Flandin, Pierre; Zhao, Yangu; Vogt, Daniel; Jeong, Juhee; Long, Jason; Potter, Gregory; Westphal, Heiner; Rubenstein, John L R.

In: Neuron, Vol. 70, No. 5, 09.06.2011, p. 939-950.

Research output: Contribution to journalArticle

Flandin, P, Zhao, Y, Vogt, D, Jeong, J, Long, J, Potter, G, Westphal, H & Rubenstein, JLR 2011, 'Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors', Neuron, vol. 70, no. 5, pp. 939-950. https://doi.org/10.1016/j.neuron.2011.04.020
Flandin, Pierre ; Zhao, Yangu ; Vogt, Daniel ; Jeong, Juhee ; Long, Jason ; Potter, Gregory ; Westphal, Heiner ; Rubenstein, John L R. / Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors. In: Neuron. 2011 ; Vol. 70, No. 5. pp. 939-950.
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