Lessons from the genomes and transcriptomes of filarial nematodes

Alexandra Grote, Sara Lustigman, Elodie Ghedin

Research output: Contribution to journalArticle

Abstract

Human filarial infections are a leading cause of morbidity in the developing world. While a small arsenal of drugs exists to treat these infections, there remains a tremendous need for the development of additional interventions. Recent genome sequences and transcriptome analyses of filarial nematodes have provided novel biological insight and allowed for the prediction of novel drug targets as well as potential vaccine candidates. In this review, we discuss the currently available data, insights gained into the metabolism of these organisms, and how the filaria field can move forward by leveraging these data.

Original languageEnglish (US)
JournalMolecular and Biochemical Parasitology
DOIs
StateAccepted/In press - Jan 11 2017

Fingerprint

Transcriptome
Genome
Gene Expression Profiling
Infection
Pharmaceutical Preparations
Sequence Analysis
Vaccines
Morbidity

Keywords

  • Filaria
  • Genomics
  • Parasitic nematodes
  • Transcriptomics

ASJC Scopus subject areas

  • Parasitology
  • Molecular Biology

Cite this

Lessons from the genomes and transcriptomes of filarial nematodes. / Grote, Alexandra; Lustigman, Sara; Ghedin, Elodie.

In: Molecular and Biochemical Parasitology, 11.01.2017.

Research output: Contribution to journalArticle

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