Leptin, lipid and lipid metabolism-related hormones in chronic renal failure in Arabia

Enyioma N. Obineche, Michael P.T. Gillett, Abdishakur Abdulle, Mustapha Sulaiman, Mona Al-Rokhaimi

    Research output: Contribution to journalArticle

    Abstract

    In patients with chronic renal failure (CRF), hyperleptinaemia has been widely reported, but the exact mechanisms leading to elevated leptin levels are unclear. Impaired renal clearance of leptin and the influence of other hormones may be important. In this study, we measured serum leptin levels in 150 patients on haemodialysis, peritoneal dialysis or in the predialysis phase of CRF. Furthermore, we measured plasma levels of insulin, growth hormone (GH) and insulin-like growth factor 1 (IGF-1), as well as plasma levels of triacylglycerols and total low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol. We observed significantly elevated levels of leptin, particularly in female patients, and leptin was shown to correlate significantly with insulin, total and LDL-cholesterol and log triacylglycerols. Leptin was inversely correlated with GH concentrations, but was not correlated with IGF-1 levels. Despite the multiple correlations established between leptin levels and other variables, only hyperinsulinaemia in CRF seems to be important as a determinator of leptin levels.

    Original languageEnglish (US)
    Pages (from-to)115-120
    Number of pages6
    JournalNephrology
    Volume7
    Issue number3
    DOIs
    StatePublished - Sep 23 2002

    Fingerprint

    Arabia
    Leptin
    Lipid Metabolism
    Chronic Kidney Failure
    Hormones
    Lipids
    Somatomedins
    Growth Hormone
    Triglycerides
    Insulin
    Hyperinsulinism
    Peritoneal Dialysis
    LDL Lipoproteins
    LDL Cholesterol
    HDL Cholesterol
    Renal Dialysis
    Kidney

    Keywords

    • Chronic renal failure
    • Growth hormone
    • Insulin
    • Insulin-like growth factor 1
    • Leptin
    • Lipids
    • United Arab Emirates

    ASJC Scopus subject areas

    • Nephrology

    Cite this

    Obineche, E. N., Gillett, M. P. T., Abdulle, A., Sulaiman, M., & Al-Rokhaimi, M. (2002). Leptin, lipid and lipid metabolism-related hormones in chronic renal failure in Arabia. Nephrology, 7(3), 115-120. https://doi.org/10.1046/j.1440-1797.2002.00102.x

    Leptin, lipid and lipid metabolism-related hormones in chronic renal failure in Arabia. / Obineche, Enyioma N.; Gillett, Michael P.T.; Abdulle, Abdishakur; Sulaiman, Mustapha; Al-Rokhaimi, Mona.

    In: Nephrology, Vol. 7, No. 3, 23.09.2002, p. 115-120.

    Research output: Contribution to journalArticle

    Obineche, EN, Gillett, MPT, Abdulle, A, Sulaiman, M & Al-Rokhaimi, M 2002, 'Leptin, lipid and lipid metabolism-related hormones in chronic renal failure in Arabia', Nephrology, vol. 7, no. 3, pp. 115-120. https://doi.org/10.1046/j.1440-1797.2002.00102.x
    Obineche, Enyioma N. ; Gillett, Michael P.T. ; Abdulle, Abdishakur ; Sulaiman, Mustapha ; Al-Rokhaimi, Mona. / Leptin, lipid and lipid metabolism-related hormones in chronic renal failure in Arabia. In: Nephrology. 2002 ; Vol. 7, No. 3. pp. 115-120.
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