Large-Scale CRISPR-Mediated Somatic Mutagenesis Identifies a Signaling Pathway that Guides Retinal Development

Olga Minkina, Claude Desplan

Research output: Contribution to journalShort survey

Abstract

As the mammalian outer retina develops, rod and cone photoreceptors synapse with their respective bipolar cells. Sarin et al. (2018) develop a somatic CRISPR technique to determine how genes differentially expressed among the four cell types mediate outer retina development. As the mammalian outer retina develops, rod and cone photoreceptors synapse with their respective bipolar cells. Sarin et al. develop a somatic CRISPR technique to determine how genes differentially expressed among the four cell types mediate outer retina development.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalNeuron
Volume98
Issue number1
DOIs
StatePublished - Apr 4 2018

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Clustered Regularly Interspaced Short Palindromic Repeats
Mutagenesis
Retina
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Synapses
Sarin
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Large-Scale CRISPR-Mediated Somatic Mutagenesis Identifies a Signaling Pathway that Guides Retinal Development. / Minkina, Olga; Desplan, Claude.

In: Neuron, Vol. 98, No. 1, 04.04.2018, p. 1-3.

Research output: Contribution to journalShort survey

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