Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Talha S. Siddiqui, Ashish Jani, Florence Williams, Robert N. Muller, Luce Vander Elst, Sophie Laurent, Fang Yao, Youssef Zaim Wadghiri, Marc A. Walters

Research output: Contribution to journalArticle

Abstract

This paper describes colloidal particles that are designed to induce hyper-intensity contrast (T1 relaxation) in MRI. The contrast agents consist of discrete gadolinium complexes tethered to 10 nm diameter silver nanoparticles. The gadolinium complexes (1) [Gd(DTPA-bisamido cysteine)]2- and (2) [Gd(cystine-NTA)2]3-, undergo chemisorption to particle surfaces through thiol or disulfide groups, respectively, to form two new contrast agents. The resulting nanoparticulate constructs are characterized on the basis of their syntheses, composition, spectra and contrast enhancing power. The average r1 relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s-1 mM-1, respectively, as compared to 4.7 s-1 mM-1 for the clinical agent MagnevistTM. Correspondingly, the respective whole particle relaxivities are 27927 and 13153 s-1 mM-1.

Original languageEnglish (US)
Pages (from-to)88-96
Number of pages9
JournalJournal of Colloid And Interface Science
Volume337
Issue number1
DOIs
StatePublished - Sep 1 2009

Keywords

  • Contrast
  • Longitudinal relaxation
  • MRI
  • Monolayer protected
  • Nanoparticles
  • Relaxivity
  • Silver

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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  • Cite this

    Siddiqui, T. S., Jani, A., Williams, F., Muller, R. N., Elst, L. V., Laurent, S., Yao, F., Wadghiri, Y. Z., & Walters, M. A. (2009). Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging. Journal of Colloid And Interface Science, 337(1), 88-96. https://doi.org/10.1016/j.jcis.2009.04.096