Lamellar bone is an incremental tissue reconciling enamel rhythms, body size, and organismal life history

Timothy Bromage, Rodrigo Lacruz, Russell Hogg, Haviva M. Goldman, Shannon C. McFarlin, Johanna Warshaw, Wendy Dirks, Alejandro Perez-Ochoa, Igor Smolyar, Donald H. Enlow, Alan Boyde

Research output: Contribution to journalArticle

Abstract

Mammalian enamel formation is periodic, including fluctuations attributable to the daily biological clock as well as longer-period oscillations that enigmatically correlate with body mass. Because the scaling of bone mass to body mass is an axiom of vertebrate hard tissue biology, we consider that long-period enamel formation rhythms may reflect corresponding and heretofore unrecognized rhythms in bone growth. The principal aim of this study is to seek a rhythm in bone growth demonstrably related to enamel oscillatory development. Our analytical approach is based in morphology, using a variety of hard tissue microscopy techniques. We first ascertain the relationship among long-period enamel rhythms, the striae of Retzius, and body mass using a large sample of mammalian taxa. In addition, we test whether osteocyte lacuna density (a surrogate for rates of cell proliferation) in bone is correlated with mammalian body mass. Finally, using fluorescently labeled developing bone tissues, we investigate whether the bone lamella, a fundamental microanatomical unit of bone, relates to rhythmic enamel growth increments. Our results confirm a positive correlation between long-period enamel rhythms and body mass and a negative correlation between osteocyte density and body mass. We also confirm that lamellar bone is an incremental tissue, one lamella formed in the species-specific time dependency of striae of Retzius formation. We conclude by contextualizing our morphological research with a current understanding of autonomic regulatory control of the skeleton and body mass, suggesting a central contribution to the coordination of organismal life history and body mass.

Original languageEnglish (US)
Pages (from-to)388-404
Number of pages17
JournalCalcified Tissue International
Volume84
Issue number5
DOIs
StatePublished - May 2009

Fingerprint

Body Size
Dental Enamel
Bone and Bones
Osteocytes
Bone Development
Biological Clocks
Skeleton
Vertebrates
Microscopy
Cell Proliferation
Growth
Research

Keywords

  • Bone lamella
  • Chronobiology
  • Enamel striae of Retzius
  • Life history

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lamellar bone is an incremental tissue reconciling enamel rhythms, body size, and organismal life history. / Bromage, Timothy; Lacruz, Rodrigo; Hogg, Russell; Goldman, Haviva M.; McFarlin, Shannon C.; Warshaw, Johanna; Dirks, Wendy; Perez-Ochoa, Alejandro; Smolyar, Igor; Enlow, Donald H.; Boyde, Alan.

In: Calcified Tissue International, Vol. 84, No. 5, 05.2009, p. 388-404.

Research output: Contribution to journalArticle

Bromage, T, Lacruz, R, Hogg, R, Goldman, HM, McFarlin, SC, Warshaw, J, Dirks, W, Perez-Ochoa, A, Smolyar, I, Enlow, DH & Boyde, A 2009, 'Lamellar bone is an incremental tissue reconciling enamel rhythms, body size, and organismal life history', Calcified Tissue International, vol. 84, no. 5, pp. 388-404. https://doi.org/10.1007/s00223-009-9221-2
Bromage, Timothy ; Lacruz, Rodrigo ; Hogg, Russell ; Goldman, Haviva M. ; McFarlin, Shannon C. ; Warshaw, Johanna ; Dirks, Wendy ; Perez-Ochoa, Alejandro ; Smolyar, Igor ; Enlow, Donald H. ; Boyde, Alan. / Lamellar bone is an incremental tissue reconciling enamel rhythms, body size, and organismal life history. In: Calcified Tissue International. 2009 ; Vol. 84, No. 5. pp. 388-404.
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