Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons

Giannina Descalzi, Virginia Gao, Michael Q. Steinman, Akinobu Suzuki, Cristina Alberini

Research output: Contribution to journalArticle

Abstract

Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally replace lactate in rescuing memory impairment caused by inhibition of glycogenolysis or expression knockdown of glia monocarboxylate transporters (MCTs) 1 and 4 in the dorsal hippocampus of rats. In contrast, either metabolite is unable to rescue memory impairment produced by expression knockdown of MCT2, which is selectively expressed by neurons, indicating that a critical role of astrocytic lactate is to provide energy for neuronal responses required for long-term memory. These responses include learning-induced mRNA translation in both excitatory and inhibitory neurons, as well as expression of Arc/Arg3.1. Thus, astrocytic lactate acts as an energy substrate to fuel learning-induced de novo neuronal translation critical for long-term memory.

Original languageEnglish (US)
Article number247
JournalCommunications Biology
Volume2
Issue number1
DOIs
StatePublished - Dec 1 2019

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astrocytes
Protein Biosynthesis
Astrocytes
Neurons
lactates
Lactic Acid
learning
neurons
Learning
Long-Term Memory
Data storage equipment
Messenger RNA
glycogenolysis
Glycogenolysis
ketone bodies
Ketone Bodies
Citric Acid Cycle
tricarboxylic acid cycle
energy
Substrates

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

Cite this

Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons. / Descalzi, Giannina; Gao, Virginia; Steinman, Michael Q.; Suzuki, Akinobu; Alberini, Cristina.

In: Communications Biology, Vol. 2, No. 1, 247, 01.12.2019.

Research output: Contribution to journalArticle

Descalzi, Giannina ; Gao, Virginia ; Steinman, Michael Q. ; Suzuki, Akinobu ; Alberini, Cristina. / Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons. In: Communications Biology. 2019 ; Vol. 2, No. 1.
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