Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor

S. Holler, V. R. Dantham, D. Keng, V. Kolchenko, Stephen Arnold

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV
PublisherSPIE
Volume9112
ISBN (Print)9781628410495
DOIs
StatePublished - 2014
EventSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV - Baltimore, MD, United States
Duration: May 5 2014May 7 2014

Other

OtherSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV
CountryUnited States
CityBaltimore, MD
Period5/5/145/7/14

Fingerprint

Whispering Gallery Modes
Whispering gallery modes
Biosensor
whispering gallery modes
Photonics
bioinstrumentation
Biosensors
markers
Labels
Cancer
cancer
photonics
proteins
Proteins
Protein
Resonator
Antenna
Resonators
antennas
resonators

Keywords

  • biosensing
  • microcavity
  • photonics
  • plasmonics
  • reactive sensing principle
  • resonance
  • single protein
  • Whispering gallery mode

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Holler, S., Dantham, V. R., Keng, D., Kolchenko, V., & Arnold, S. (2014). Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor. In Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV (Vol. 9112). [911217] SPIE. https://doi.org/10.1117/12.2050222

Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor. / Holler, S.; Dantham, V. R.; Keng, D.; Kolchenko, V.; Arnold, Stephen.

Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV. Vol. 9112 SPIE, 2014. 911217.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Holler, S, Dantham, VR, Keng, D, Kolchenko, V & Arnold, S 2014, Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor. in Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV. vol. 9112, 911217, SPIE, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV, Baltimore, MD, United States, 5/5/14. https://doi.org/10.1117/12.2050222
Holler S, Dantham VR, Keng D, Kolchenko V, Arnold S. Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor. In Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV. Vol. 9112. SPIE. 2014. 911217 https://doi.org/10.1117/12.2050222
Holler, S. ; Dantham, V. R. ; Keng, D. ; Kolchenko, V. ; Arnold, Stephen. / Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor. Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV. Vol. 9112 SPIE, 2014.
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