Abstract
The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.
| Original language | English (US) |
|---|---|
| Title of host publication | Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV |
| Publisher | SPIE |
| Volume | 9112 |
| ISBN (Print) | 9781628410495 |
| DOIs | |
| State | Published - 2014 |
| Event | Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV - Baltimore, MD, United States Duration: May 5 2014 → May 7 2014 |
Other
| Other | Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV |
|---|---|
| Country | United States |
| City | Baltimore, MD |
| Period | 5/5/14 → 5/7/14 |
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Keywords
- biosensing
- microcavity
- photonics
- plasmonics
- reactive sensing principle
- resonance
- single protein
- Whispering gallery mode
ASJC Scopus subject areas
- Applied Mathematics
- Computer Science Applications
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
Cite this
Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor. / Holler, S.; Dantham, V. R.; Keng, D.; Kolchenko, V.; Arnold, Stephen.
Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV. Vol. 9112 SPIE, 2014. 911217.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor
AU - Holler, S.
AU - Dantham, V. R.
AU - Keng, D.
AU - Kolchenko, V.
AU - Arnold, Stephen
PY - 2014
Y1 - 2014
N2 - The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.
AB - The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.
KW - biosensing
KW - microcavity
KW - photonics
KW - plasmonics
KW - reactive sensing principle
KW - resonance
KW - single protein
KW - Whispering gallery mode
UR - http://www.scopus.com/inward/record.url?scp=84907042731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907042731&partnerID=8YFLogxK
U2 - 10.1117/12.2050222
DO - 10.1117/12.2050222
M3 - Conference contribution
AN - SCOPUS:84907042731
SN - 9781628410495
VL - 9112
BT - Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV
PB - SPIE
ER -