L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish

Anthony V. Furano, David D. Duvernell, Stephane Boissinot

Research output: Contribution to journalReview article

Abstract

L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ∼80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ∼20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalTrends in Genetics
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Retroelements
Mammals
Fishes
DNA
Long Interspersed Nucleotide Elements
Zebrafish
History
RNA

ASJC Scopus subject areas

  • Genetics

Cite this

L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish. / Furano, Anthony V.; Duvernell, David D.; Boissinot, Stephane.

In: Trends in Genetics, Vol. 20, No. 1, 01.01.2004, p. 9-14.

Research output: Contribution to journalReview article

Furano, Anthony V. ; Duvernell, David D. ; Boissinot, Stephane. / L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish. In: Trends in Genetics. 2004 ; Vol. 20, No. 1. pp. 9-14.
@article{ac7967ae4f124db6997a8dd3feb2ac22,
title = "L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish",
abstract = "L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ∼80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ∼20{\%} of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.",
author = "Furano, {Anthony V.} and Duvernell, {David D.} and Stephane Boissinot",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.tig.2003.11.006",
language = "English (US)",
volume = "20",
pages = "9--14",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish

AU - Furano, Anthony V.

AU - Duvernell, David D.

AU - Boissinot, Stephane

PY - 2004/1/1

Y1 - 2004/1/1

N2 - L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ∼80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ∼20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

AB - L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ∼80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ∼20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

UR - http://www.scopus.com/inward/record.url?scp=0348048755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0348048755&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2003.11.006

DO - 10.1016/j.tig.2003.11.006

M3 - Review article

C2 - 14698614

AN - SCOPUS:0348048755

VL - 20

SP - 9

EP - 14

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 1

ER -