L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish

Anthony V. Furano, David D. Duvernell, Stephane Boissinot

    Research output: Contribution to journalReview article

    Abstract

    L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ∼80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ∼20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

    Original languageEnglish (US)
    Pages (from-to)9-14
    Number of pages6
    JournalTrends in Genetics
    Volume20
    Issue number1
    DOIs
    StatePublished - Jan 1 2004

    Fingerprint

    Retroelements
    Mammals
    Fishes
    DNA
    Long Interspersed Nucleotide Elements
    Zebrafish
    History
    RNA

    ASJC Scopus subject areas

    • Genetics

    Cite this

    L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish. / Furano, Anthony V.; Duvernell, David D.; Boissinot, Stephane.

    In: Trends in Genetics, Vol. 20, No. 1, 01.01.2004, p. 9-14.

    Research output: Contribution to journalReview article

    Furano, Anthony V. ; Duvernell, David D. ; Boissinot, Stephane. / L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish. In: Trends in Genetics. 2004 ; Vol. 20, No. 1. pp. 9-14.
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