Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships

Michelle L. Wright, Erin B. Ware, Jennifer A. Smith, Sharon L.R. Kardia, Jacquelyn Taylor

Research output: Contribution to journalArticle

Abstract

Introduction: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations. Methods: The purpose of this study was to determine whether single-nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) differences contribute to lipid variation among African Americans ([AAs], N = 739) in the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Results: Previous meta-analyses identified 161 SNPs that are associated with lipid traits in populations of EA. We evaluated these SNPs and 66 DNAm sites within the genes containing the SNPs in the GENOA cohort using linear mixed-effects modeling. We did not identify any significant associations of SNPs or DNAm with serum lipid levels. These results suggest that the SNPs identified as being significant for lipid levels through the EA genome-wide association studies may not be significant across AA populations. Conclusions: Reductions in morbidity and mortality due to variation in lipids among AAs may be achieved through a better understanding of the genetic and epigenetic factors associated with serum lipid levels for early and appropriate screening. Further large-scale studies specifically within AA and other non-EA populations are warranted.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalBiological Research for Nursing
Volume20
Issue number2
DOIs
StatePublished - Mar 1 2018

Fingerprint

DNA Methylation
African Americans
Single Nucleotide Polymorphism
Joints
Lipids
Molecular Epidemiology
Cholesterol
Serum
Epigenomics
Population
Genome-Wide Association Study
Meta-Analysis
Triglycerides
Cardiovascular Diseases
Morbidity
Mortality

Keywords

  • African Americans
  • cholesterol
  • DNA methylation
  • genetic research
  • GENOA
  • lipids

ASJC Scopus subject areas

  • Research and Theory

Cite this

Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships. / Wright, Michelle L.; Ware, Erin B.; Smith, Jennifer A.; Kardia, Sharon L.R.; Taylor, Jacquelyn.

In: Biological Research for Nursing, Vol. 20, No. 2, 01.03.2018, p. 161-167.

Research output: Contribution to journalArticle

Wright, Michelle L. ; Ware, Erin B. ; Smith, Jennifer A. ; Kardia, Sharon L.R. ; Taylor, Jacquelyn. / Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships. In: Biological Research for Nursing. 2018 ; Vol. 20, No. 2. pp. 161-167.
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