Ionic basis for intrinsic 40 hz neuronal oscillations

Research output: Contribution to journalArticle

Abstract

We present a biophysical model of a slowly inactivating potassium ion current IKS, based on recent voltage-clamp data from layer V pyramidal neurons in the cat sensori-motor cortex and show that the interplay between a persistent sodium current INaP and IKS is able to produce intrinsic membrane potential oscillations in the 10- to 50-frequency range. A most notable characteristic of such rhythmicity is what may be termed mixed-mode bursting, where clusters of action potentials alternate in time with epochs of small subthreshold oscillations.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalNeuroReport
Volume5
Issue number3
StatePublished - 1993

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Pyramidal Cells
Motor Cortex
Periodicity
Membrane Potentials
Action Potentials
Potassium
Cats
Sodium
Ions

Keywords

  • 40 hz brain rhythm
  • Biophysical model
  • Clustering of na<sup>+</sup> spikes
  • Hodgkin-huxley formalism
  • Mixed-mode bursting
  • Persistent sodium channel
  • Slowly inactivating potassium channel
  • Subthreshold oscillation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ionic basis for intrinsic 40 hz neuronal oscillations. / Wang, Xiao-Jing.

In: NeuroReport, Vol. 5, No. 3, 1993, p. 221-224.

Research output: Contribution to journalArticle

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