Invited review of a workshop: Anabolic hormones in bone: Basic research and therapeutic potential

Ronald N. Margolis, Ernesto Canalis, Nicola Partridge

Research output: Contribution to journalArticle

Abstract

Age-, postmenopause-, and disease-related conditions that result in low bone mass represent important public health issues. Maintenance of bone mass is a balance between bone resorption and formation and is influenced by diet, body composition, activity level, and the interactions between and among a large number of hormones, growth factors, and cytokines. Recent research has emphasized establishing a more complete understanding of the hormonal regulation of bone and developing anabolic agents with therapeutic potential for the treatment of low bone mass. The NIDDK at the NIH recently sponsored a Workshop, entitled Anabolic Hormones in Bone: Basic Research and Therapeutic Potential, that attempted to define the current state of the art knowledge of hormones, growth factors, and cytokines that affect bone mass, with particular emphasis on those that could potentially have a role as anabolic agents in bone. This review presents a condensed proceedings of that workshop along with a summary of the optimal requisites for the development of anabolic agents with therapeutic potential in bone.

Original languageEnglish (US)
Pages (from-to)872-877
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume81
Issue number3
DOIs
StatePublished - 1996

Fingerprint

Therapeutic Human Experimentation
Bone
Hormones
Education
Bone and Bones
Anabolic Agents
Intercellular Signaling Peptides and Proteins
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Cytokines
Postmenopause
Bone Resorption
Body Composition
Osteogenesis
Public health
Nutrition
Public Health
Maintenance
Diet

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Invited review of a workshop : Anabolic hormones in bone: Basic research and therapeutic potential. / Margolis, Ronald N.; Canalis, Ernesto; Partridge, Nicola.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 81, No. 3, 1996, p. 872-877.

Research output: Contribution to journalArticle

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