Invited review article: Combining scanning probe microscopy with optical spectroscopy for applications in biology and materials science

Marcel Lucas, Elisa Riedo

Research output: Contribution to journalReview article

Abstract

This is a comprehensive review of the combination of scanning probe microscopy (SPM) with various optical spectroscopies, with a particular focus on Raman spectroscopy. Efforts to combine SPM with optical spectroscopy will be described, and the technical difficulties encountered will be examined. These efforts have so far focused mainly on the development of tip-enhanced Raman spectroscopy, a powerful technique to detect and image chemical signatures with single molecule sensitivity, which will be reviewed. Beyond tip-enhanced Raman spectroscopy andor topography measurements, combinations of SPM with optical spectroscopy have a great potential in the characterization of structure and quantitative measurements of physical properties, such as mechanical, optical, or electrical properties, in delicate biological samples and nanomaterials. The different approaches to improve the spatial resolution, the chemical sensitivity, and the accuracy of physical properties measurements will be discussed. Applications of such combinations for the characterization of structure, defects, and physical properties in biology and materials science will be reviewed. Due to the versatility of SPM probes for the manipulation and characterization of small andor delicate samples, this review will mainly focus on the apertureless techniques based on SPM probes.

Original languageEnglish (US)
Article number061101
JournalReview of Scientific Instruments
Volume83
Issue number6
DOIs
StatePublished - Jun 1 2012

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Scanning probe microscopy
Materials science
materials science
biology
microscopy
scanning
probes
Raman spectroscopy
Physical properties
spectroscopy
physical properties
Defect structures
Nanostructured materials
Topography
Electric properties
Optical properties
versatility
Optical spectroscopy
manipulators
Molecules

ASJC Scopus subject areas

  • Instrumentation

Cite this

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abstract = "This is a comprehensive review of the combination of scanning probe microscopy (SPM) with various optical spectroscopies, with a particular focus on Raman spectroscopy. Efforts to combine SPM with optical spectroscopy will be described, and the technical difficulties encountered will be examined. These efforts have so far focused mainly on the development of tip-enhanced Raman spectroscopy, a powerful technique to detect and image chemical signatures with single molecule sensitivity, which will be reviewed. Beyond tip-enhanced Raman spectroscopy andor topography measurements, combinations of SPM with optical spectroscopy have a great potential in the characterization of structure and quantitative measurements of physical properties, such as mechanical, optical, or electrical properties, in delicate biological samples and nanomaterials. The different approaches to improve the spatial resolution, the chemical sensitivity, and the accuracy of physical properties measurements will be discussed. Applications of such combinations for the characterization of structure, defects, and physical properties in biology and materials science will be reviewed. Due to the versatility of SPM probes for the manipulation and characterization of small andor delicate samples, this review will mainly focus on the apertureless techniques based on SPM probes.",
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