Investigating large-scale brain dynamics using field potential recordings

analysis and interpretation

Bijan Pesaran, Martin Vinck, Gaute T. Einevoll, Anton Sirota, Pascal Fries, Markus Siegel, Wilson Truccolo, Charles E. Schroeder, Ramesh Srinivasan

Research output: Contribution to journalArticle

Abstract

New technologies to record electrical activity from the brain on a massive scale offer tremendous opportunities for discovery. Electrical measurements of large-scale brain dynamics, termed field potentials, are especially important to understanding and treating the human brain. Here, our goal is to provide best practices on how field potential recordings (electroencephalograms, magnetoencephalograms, electrocorticograms and local field potentials) can be analyzed to identify large-scale brain dynamics, and to highlight critical issues and limitations of interpretation in current work. We focus our discussion of analyses around the broad themes of activation, correlation, communication and coding. We provide recommendations for interpreting the data using forward and inverse models. The forward model describes how field potentials are generated by the activity of populations of neurons. The inverse model describes how to infer the activity of populations of neurons from field potential recordings. A recurring theme is the challenge of understanding how field potentials reflect neuronal population activity given the complexity of the underlying brain systems.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalNature Neuroscience
DOIs
StateAccepted/In press - Jun 25 2018

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Brain
Population
Neurons
Practice Guidelines
Electroencephalography
Communication
Technology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Investigating large-scale brain dynamics using field potential recordings : analysis and interpretation. / Pesaran, Bijan; Vinck, Martin; Einevoll, Gaute T.; Sirota, Anton; Fries, Pascal; Siegel, Markus; Truccolo, Wilson; Schroeder, Charles E.; Srinivasan, Ramesh.

In: Nature Neuroscience, 25.06.2018, p. 1-17.

Research output: Contribution to journalArticle

Pesaran, B, Vinck, M, Einevoll, GT, Sirota, A, Fries, P, Siegel, M, Truccolo, W, Schroeder, CE & Srinivasan, R 2018, 'Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation', Nature Neuroscience, pp. 1-17. https://doi.org/10.1038/s41593-018-0171-8
Pesaran, Bijan ; Vinck, Martin ; Einevoll, Gaute T. ; Sirota, Anton ; Fries, Pascal ; Siegel, Markus ; Truccolo, Wilson ; Schroeder, Charles E. ; Srinivasan, Ramesh. / Investigating large-scale brain dynamics using field potential recordings : analysis and interpretation. In: Nature Neuroscience. 2018 ; pp. 1-17.
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