Inverse Correlation between Lethality and Thermodynamic Stability of Contact Insecticide Polymorphs

Jingxiang Yang, Xiaolong Zhu, Chunhua T. Hu, Mengdi Qiu, Qiang Zhu, Michael Ward, Bart Kahr

Research output: Contribution to journalArticle

Abstract

Contact insecticides often involve the interaction of whole organisms and toxicant crystal surfaces. The crystalline phase of these compounds has not, however, been considered for the optimization of insecticide performance. Lindane (1R,2r,3S,4R,5r,6S-hexachlorocyclohexane) has been one of the most widely used insecticides, but other (inactive) stereoisomers accompanying its manufacture have led to massive chemical waste remediation problems. Crystalline polymorphs are also isomers in the broadest sense, yet only one crystal structure of lindane has been reported. Herein, we report the discovery and characterization of two new polymorphs, Forms II and III. The efficacy of Forms I, II, and III against Drosophila melanogaster revealed an inverse correlation between lethality and thermodynamic stability; the least stable kills fastest. This understanding provides a crystal engineering opportunity wherein formulations containing the most active contact insecticide polymorph can achieve infectious disease prophylaxis while reducing environmental exposure and associated chemical waste.

Original languageEnglish (US)
Pages (from-to)1839-1844
Number of pages6
JournalCrystal Growth and Design
Volume19
Issue number3
DOIs
StatePublished - Mar 6 2019

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insecticides
lethality
Insecticides
Polymorphism
Lindane
Thermodynamic stability
Chemical wastes
thermodynamics
prophylaxis
Crystal engineering
Crystalline materials
Drosophila
Stereoisomerism
infectious diseases
Crystallization
Remediation
organisms
crystal surfaces
Isomers
isomers

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Inverse Correlation between Lethality and Thermodynamic Stability of Contact Insecticide Polymorphs. / Yang, Jingxiang; Zhu, Xiaolong; Hu, Chunhua T.; Qiu, Mengdi; Zhu, Qiang; Ward, Michael; Kahr, Bart.

In: Crystal Growth and Design, Vol. 19, No. 3, 06.03.2019, p. 1839-1844.

Research output: Contribution to journalArticle

Yang, Jingxiang ; Zhu, Xiaolong ; Hu, Chunhua T. ; Qiu, Mengdi ; Zhu, Qiang ; Ward, Michael ; Kahr, Bart. / Inverse Correlation between Lethality and Thermodynamic Stability of Contact Insecticide Polymorphs. In: Crystal Growth and Design. 2019 ; Vol. 19, No. 3. pp. 1839-1844.
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