Inverse associations of Helicobacter pylori with asthma and allergy

Yu Chen, Martin J. Blaser

Research output: Contribution to journalArticle

Abstract

Background: Acquisition of Helicobacter pylori, which predominantly occurs before age 10 years, may reduce risks of asthma and allergy. Methods: We evaluated the associations of H pylori status with history of asthma and allergy and with skin sensitization using data from 7663 adults in the Third National Health and Nutrition Examination Survey. Adjusted odds ratios (ORs) for currently and ever having asthma, allergic rhinitis, allergy symptoms in the previous year, and allergen-specific skin sensitization were computed comparing participants seropositive for cagA? or cagA+ strains of H pylori with those without H pylori. Results: The presence of cagA+ H pylori strains was inversely related to ever having asthma (OR, 0.79; 95% confidence interval [CI], 0.63-0.99), and the inverse association of cagA positivity with childhood-onset (age ≤15 years) asthma was stronger (OR, 0.63; 95% CI, 0.43-0.93) than that with adult-onset asthma (OR, 0.97; 95% CI, 0.72-1.32). Colonization with H pylori, especially with a cagA+ strain, was inversely associated with currently (OR, 0.77; 95% CI, 0.62-0.96) or ever (OR, 0.77; 95% CI, 0.62-0.94) having a diagnosis of allergic rhinitis, especially for childhood onset (OR, 0.55; 95% CI, 0.37-0.82). Consistent inverse associations were found between H pylori colonization and the presence of allergy symptoms in the previous year and sensitization to pollens and molds. Conclusion: These observations support the hypothesis that childhood acquisition of H pylori is associated with reduced risks of asthma and allergy.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalArchives of Internal Medicine
Volume167
Issue number8
DOIs
StatePublished - Apr 23 2007

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Pylorus
Helicobacter pylori
Hypersensitivity
Asthma
Odds Ratio
Confidence Intervals
Skin
Nutrition Surveys
Pollen
Age of Onset
Allergens
Fungi

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Inverse associations of Helicobacter pylori with asthma and allergy. / Chen, Yu; Blaser, Martin J.

In: Archives of Internal Medicine, Vol. 167, No. 8, 23.04.2007, p. 821-827.

Research output: Contribution to journalArticle

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