Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine

Paul M. Levine, Timothy W. Craven, Richard Bonneau, Kent Kirshenbaum

Research output: Contribution to journalArticle

Abstract

Recently developed chemical ligation protocols were elaborated for rapid N-terminal protein PEGylation. We introduce a PEG-salicylaldehyde ester and demonstrate its site-specific ligation to the N-terminus of the RNase S protein and to the therapeutic polypeptide PTH (1–34).

Original languageEnglish (US)
Pages (from-to)6909-6912
Number of pages4
JournalChemical Communications
Volume50
Issue number52
DOIs
StatePublished - Jun 3 2014

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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