Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake

Victoria N. Luine, Maya Frankfurt, Thomas C. Rainbow, Anat Biegon, Efrain Azmitia

Research output: Contribution to journalArticle

Abstract

5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [3H]5-HT but not [3H]NE uptake in the whole hypothalamus and with decreased [3H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalBrain Research
Volume264
Issue number2
DOIs
StatePublished - Apr 4 1983

Fingerprint

5,7-Dihydroxytryptamine
Imipramine
Sexual Behavior
Hypothalamus
Serotonin
Estrogens
Hormones
Neurons
Inhibition (Psychology)

Keywords

  • 5,7-dihydroxytryptamine
  • lordosis behavior
  • serotonin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake. / Luine, Victoria N.; Frankfurt, Maya; Rainbow, Thomas C.; Biegon, Anat; Azmitia, Efrain.

In: Brain Research, Vol. 264, No. 2, 04.04.1983, p. 344-348.

Research output: Contribution to journalArticle

Luine, Victoria N. ; Frankfurt, Maya ; Rainbow, Thomas C. ; Biegon, Anat ; Azmitia, Efrain. / Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake. In: Brain Research. 1983 ; Vol. 264, No. 2. pp. 344-348.
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