Intracellular signal transduction as a factor in the development of "Smart" biomaterials for bone tissue engineering

Willian F. Zambuzzi, Paulo Coelho, Gutemberg G. Alves, José M. Granjeiro

Research output: Contribution to journalArticle

Abstract

Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell-related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel "smart" materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation.

Original languageEnglish (US)
Pages (from-to)1246-1250
Number of pages5
JournalBiotechnology and Bioengineering
Volume108
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Signal transduction
Biocompatible Materials
Tissue Engineering
Tissue engineering
Biomaterials
Cell Adhesion
Signal Transduction
Bone
Phosphorylation
Adhesion
Cell adhesion
Bone and Bones
Focal Adhesion Protein-Tyrosine Kinases
Focal Adhesions
Osteoblasts
Protein-Tyrosine Kinases
Energy Metabolism
Cell Movement
Tyrosine
Intelligent materials

Keywords

  • Bioengineering
  • Biotechnology
  • Cell adhesion
  • Implant
  • Material development
  • Signal transduction

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Intracellular signal transduction as a factor in the development of "Smart" biomaterials for bone tissue engineering. / Zambuzzi, Willian F.; Coelho, Paulo; Alves, Gutemberg G.; Granjeiro, José M.

In: Biotechnology and Bioengineering, Vol. 108, No. 6, 06.2011, p. 1246-1250.

Research output: Contribution to journalArticle

Zambuzzi, Willian F. ; Coelho, Paulo ; Alves, Gutemberg G. ; Granjeiro, José M. / Intracellular signal transduction as a factor in the development of "Smart" biomaterials for bone tissue engineering. In: Biotechnology and Bioengineering. 2011 ; Vol. 108, No. 6. pp. 1246-1250.
@article{9ec05f53d7a2490c980be751d340ecdf,
title = "Intracellular signal transduction as a factor in the development of {"}Smart{"} biomaterials for bone tissue engineering",
abstract = "Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell-related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel {"}smart{"} materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation.",
keywords = "Bioengineering, Biotechnology, Cell adhesion, Implant, Material development, Signal transduction",
author = "Zambuzzi, {Willian F.} and Paulo Coelho and Alves, {Gutemberg G.} and Granjeiro, {Jos{\'e} M.}",
year = "2011",
month = "6",
doi = "10.1002/bit.23117",
language = "English (US)",
volume = "108",
pages = "1246--1250",
journal = "Biotechnology and Bioengineering",
issn = "0006-3592",
publisher = "Wiley-VCH Verlag",
number = "6",

}

TY - JOUR

T1 - Intracellular signal transduction as a factor in the development of "Smart" biomaterials for bone tissue engineering

AU - Zambuzzi, Willian F.

AU - Coelho, Paulo

AU - Alves, Gutemberg G.

AU - Granjeiro, José M.

PY - 2011/6

Y1 - 2011/6

N2 - Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell-related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel "smart" materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation.

AB - Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell-related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel "smart" materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation.

KW - Bioengineering

KW - Biotechnology

KW - Cell adhesion

KW - Implant

KW - Material development

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=79954482003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954482003&partnerID=8YFLogxK

U2 - 10.1002/bit.23117

DO - 10.1002/bit.23117

M3 - Article

C2 - 21351075

AN - SCOPUS:79954482003

VL - 108

SP - 1246

EP - 1250

JO - Biotechnology and Bioengineering

JF - Biotechnology and Bioengineering

SN - 0006-3592

IS - 6

ER -