Intra-oral comparison and evaluation of the ability of fluoride dentifrices to promote the remineralization of Caries-like lesions in dentin and enamel

R. J. Sullivan, R. Fletcher, Rima Sehl, Bapanaiah Penugonda, R. Z. LeGeros

Research output: Contribution to journalArticle

Abstract

The effect of three types of fluoride dentifrices and one non-fluoride dentifrice were evaluated and compared intra-orally for their ability to promote the remineralization of caries-like lesions in thin sections of human dentin and enamel. The three fluoride dentifrices were silica based. One dentifrice contained 0.76% sodium monofluorophosphate (MFP), another contained 0.247% sodium fluoride (NaF), and the third contained 0.247% NaF plus 1.3% pyrophosphate and 1.5% polyvinylmethyl ether/maleic acid (PVM/MA) copolymer (denoted NaF/PP(i)). The fourth dentifrice (placebo) was also silica based, but contained no fluoride, and served as a negative control. Two week treatment resulted in the following percent mineral changes for the enamel specimens: +21 ± 16 for MFP, +10 ± 30 for NaF, +16 ± 15 for NaF/PP(i), and -30 ± 30 for the placebo. The respective percent mineral change values for the dentin specimens were +28 ± 20 for MFP, +22 ± 19 for NaF, +28 ± 18 for NaF/PP(i), and -34 ± 61 for the placebo. A statistical analysis revealed that the three fluoride dentifrices were significantly better (p < 0.05) than the placebo at promoting remineralization for both types of specimens. No significant differences were found among the three fluoride dentifrices. The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalJournal of Clinical Dentistry
Volume6
Issue number2
StatePublished - 1995

Fingerprint

fluorophosphate
Dentifrices
Dentin
Dental Enamel
Fluorides
Placebos
Silicon Dioxide
Minerals
Sodium Fluoride

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

@article{43e1e2222b2044dd80197430d03723b2,
title = "Intra-oral comparison and evaluation of the ability of fluoride dentifrices to promote the remineralization of Caries-like lesions in dentin and enamel",
abstract = "The effect of three types of fluoride dentifrices and one non-fluoride dentifrice were evaluated and compared intra-orally for their ability to promote the remineralization of caries-like lesions in thin sections of human dentin and enamel. The three fluoride dentifrices were silica based. One dentifrice contained 0.76{\%} sodium monofluorophosphate (MFP), another contained 0.247{\%} sodium fluoride (NaF), and the third contained 0.247{\%} NaF plus 1.3{\%} pyrophosphate and 1.5{\%} polyvinylmethyl ether/maleic acid (PVM/MA) copolymer (denoted NaF/PP(i)). The fourth dentifrice (placebo) was also silica based, but contained no fluoride, and served as a negative control. Two week treatment resulted in the following percent mineral changes for the enamel specimens: +21 ± 16 for MFP, +10 ± 30 for NaF, +16 ± 15 for NaF/PP(i), and -30 ± 30 for the placebo. The respective percent mineral change values for the dentin specimens were +28 ± 20 for MFP, +22 ± 19 for NaF, +28 ± 18 for NaF/PP(i), and -34 ± 61 for the placebo. A statistical analysis revealed that the three fluoride dentifrices were significantly better (p < 0.05) than the placebo at promoting remineralization for both types of specimens. No significant differences were found among the three fluoride dentifrices. The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF.",
author = "Sullivan, {R. J.} and R. Fletcher and Rima Sehl and Bapanaiah Penugonda and LeGeros, {R. Z.}",
year = "1995",
language = "English (US)",
volume = "6",
pages = "135--138",
journal = "Journal of Clinical Dentistry",
issn = "0895-8831",
publisher = "Professional Audience Communications Inc.",
number = "2",

}

TY - JOUR

T1 - Intra-oral comparison and evaluation of the ability of fluoride dentifrices to promote the remineralization of Caries-like lesions in dentin and enamel

AU - Sullivan, R. J.

AU - Fletcher, R.

AU - Sehl, Rima

AU - Penugonda, Bapanaiah

AU - LeGeros, R. Z.

PY - 1995

Y1 - 1995

N2 - The effect of three types of fluoride dentifrices and one non-fluoride dentifrice were evaluated and compared intra-orally for their ability to promote the remineralization of caries-like lesions in thin sections of human dentin and enamel. The three fluoride dentifrices were silica based. One dentifrice contained 0.76% sodium monofluorophosphate (MFP), another contained 0.247% sodium fluoride (NaF), and the third contained 0.247% NaF plus 1.3% pyrophosphate and 1.5% polyvinylmethyl ether/maleic acid (PVM/MA) copolymer (denoted NaF/PP(i)). The fourth dentifrice (placebo) was also silica based, but contained no fluoride, and served as a negative control. Two week treatment resulted in the following percent mineral changes for the enamel specimens: +21 ± 16 for MFP, +10 ± 30 for NaF, +16 ± 15 for NaF/PP(i), and -30 ± 30 for the placebo. The respective percent mineral change values for the dentin specimens were +28 ± 20 for MFP, +22 ± 19 for NaF, +28 ± 18 for NaF/PP(i), and -34 ± 61 for the placebo. A statistical analysis revealed that the three fluoride dentifrices were significantly better (p < 0.05) than the placebo at promoting remineralization for both types of specimens. No significant differences were found among the three fluoride dentifrices. The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF.

AB - The effect of three types of fluoride dentifrices and one non-fluoride dentifrice were evaluated and compared intra-orally for their ability to promote the remineralization of caries-like lesions in thin sections of human dentin and enamel. The three fluoride dentifrices were silica based. One dentifrice contained 0.76% sodium monofluorophosphate (MFP), another contained 0.247% sodium fluoride (NaF), and the third contained 0.247% NaF plus 1.3% pyrophosphate and 1.5% polyvinylmethyl ether/maleic acid (PVM/MA) copolymer (denoted NaF/PP(i)). The fourth dentifrice (placebo) was also silica based, but contained no fluoride, and served as a negative control. Two week treatment resulted in the following percent mineral changes for the enamel specimens: +21 ± 16 for MFP, +10 ± 30 for NaF, +16 ± 15 for NaF/PP(i), and -30 ± 30 for the placebo. The respective percent mineral change values for the dentin specimens were +28 ± 20 for MFP, +22 ± 19 for NaF, +28 ± 18 for NaF/PP(i), and -34 ± 61 for the placebo. A statistical analysis revealed that the three fluoride dentifrices were significantly better (p < 0.05) than the placebo at promoting remineralization for both types of specimens. No significant differences were found among the three fluoride dentifrices. The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF.

UR - http://www.scopus.com/inward/record.url?scp=0028842831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028842831&partnerID=8YFLogxK

M3 - Article

C2 - 8624224

AN - SCOPUS:0028842831

VL - 6

SP - 135

EP - 138

JO - Journal of Clinical Dentistry

JF - Journal of Clinical Dentistry

SN - 0895-8831

IS - 2

ER -