Interleukin-2 levels are associated with carotid artery intima-media thickness

Mitchell S V Elkind, Tanja Rundek, Robert R. Sciacca, Romel Ramas, Hong Jun Chen, Bernadette Boden-Albala, LeRoy Rabbani, Ralph L. Sacco

Research output: Contribution to journalArticle

Abstract

Objective: To show that serum interleukin levels are associated with carotid intima-media thickness (IMT). Background: Inflammation is hypothesized to play a central role in atherogenesis, and serum markers of inflammation are predictive of cardiovascular disease. Interleukin-2, a pro-inflammatory cytokine produced largely by naive CD4 T cells and Th1 (pro-inflammatory) T cells, has been found in a high proportion of carotid plaques. Methods: High-resolution ultrasound of the carotid arteries and serum cytokine levels were measured in stroke-free participants. The mean of the maximum IMT in bilateral bifurcation, common and internal carotid artery segments was measured. Serum levels of interleukin (IL)-1beta, IL-2, IL-6, C-reactive protein, tumor necrosis factor (TNF) alpha and TNF receptors were measured using enzyme-linked immunosorbent assay. Results: IL-2 levels were significantly correlated with IMT (r = 0.33, P < 0.0001), but other cytokines were not. Each unit increase in IL-2 was significantly associated with a mean increase in IMT of 0.18 mm (P = 0.0001). After adjusting for other atherosclerotic risk factors, the association was unchanged (mean increase in IMT per unit increase IL-2 = 0.18 mm, P < 0.0001). Each standard deviation increase in the level of IL-2 was associated with an increased risk (adjusted odds ratio 1.80, 95% CI 1.12-2.89) for an IMT ≥ 1.0 mm (75th percentile for IMT). Conclusion: Serum levels of IL-2, a pro-inflammatory cytokine, are associated with carotid artery IMT, a predictor of stroke and vascular disease. Serum inflammatory markers may provide a novel marker of atherosclerotic risk, and inflammation may provide a new therapeutic target for stroke prevention.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalAtherosclerosis
Volume180
Issue number1
DOIs
StatePublished - May 2005

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Carotid Intima-Media Thickness
Carotid Arteries
Interleukin-2
Cytokines
Stroke
Inflammation
Serum
Biomarkers
T-Lymphocytes
Tumor Necrosis Factor Receptors
Interleukins
Common Carotid Artery
Internal Carotid Artery
Interleukin-1beta
Vascular Diseases
C-Reactive Protein
Interleukin-6
Atherosclerosis
Cardiovascular Diseases
Tumor Necrosis Factor-alpha

Keywords

  • Atherosclerosis
  • Cytokines
  • Epidemiology
  • Interleukin-2
  • Intima-media thickness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Elkind, M. S. V., Rundek, T., Sciacca, R. R., Ramas, R., Chen, H. J., Boden-Albala, B., ... Sacco, R. L. (2005). Interleukin-2 levels are associated with carotid artery intima-media thickness. Atherosclerosis, 180(1), 181-187. https://doi.org/10.1016/j.atherosclerosis.2004.11.015

Interleukin-2 levels are associated with carotid artery intima-media thickness. / Elkind, Mitchell S V; Rundek, Tanja; Sciacca, Robert R.; Ramas, Romel; Chen, Hong Jun; Boden-Albala, Bernadette; Rabbani, LeRoy; Sacco, Ralph L.

In: Atherosclerosis, Vol. 180, No. 1, 05.2005, p. 181-187.

Research output: Contribution to journalArticle

Elkind, MSV, Rundek, T, Sciacca, RR, Ramas, R, Chen, HJ, Boden-Albala, B, Rabbani, L & Sacco, RL 2005, 'Interleukin-2 levels are associated with carotid artery intima-media thickness', Atherosclerosis, vol. 180, no. 1, pp. 181-187. https://doi.org/10.1016/j.atherosclerosis.2004.11.015
Elkind, Mitchell S V ; Rundek, Tanja ; Sciacca, Robert R. ; Ramas, Romel ; Chen, Hong Jun ; Boden-Albala, Bernadette ; Rabbani, LeRoy ; Sacco, Ralph L. / Interleukin-2 levels are associated with carotid artery intima-media thickness. In: Atherosclerosis. 2005 ; Vol. 180, No. 1. pp. 181-187.
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abstract = "Objective: To show that serum interleukin levels are associated with carotid intima-media thickness (IMT). Background: Inflammation is hypothesized to play a central role in atherogenesis, and serum markers of inflammation are predictive of cardiovascular disease. Interleukin-2, a pro-inflammatory cytokine produced largely by naive CD4 T cells and Th1 (pro-inflammatory) T cells, has been found in a high proportion of carotid plaques. Methods: High-resolution ultrasound of the carotid arteries and serum cytokine levels were measured in stroke-free participants. The mean of the maximum IMT in bilateral bifurcation, common and internal carotid artery segments was measured. Serum levels of interleukin (IL)-1beta, IL-2, IL-6, C-reactive protein, tumor necrosis factor (TNF) alpha and TNF receptors were measured using enzyme-linked immunosorbent assay. Results: IL-2 levels were significantly correlated with IMT (r = 0.33, P < 0.0001), but other cytokines were not. Each unit increase in IL-2 was significantly associated with a mean increase in IMT of 0.18 mm (P = 0.0001). After adjusting for other atherosclerotic risk factors, the association was unchanged (mean increase in IMT per unit increase IL-2 = 0.18 mm, P < 0.0001). Each standard deviation increase in the level of IL-2 was associated with an increased risk (adjusted odds ratio 1.80, 95{\%} CI 1.12-2.89) for an IMT ≥ 1.0 mm (75th percentile for IMT). Conclusion: Serum levels of IL-2, a pro-inflammatory cytokine, are associated with carotid artery IMT, a predictor of stroke and vascular disease. Serum inflammatory markers may provide a novel marker of atherosclerotic risk, and inflammation may provide a new therapeutic target for stroke prevention.",
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AU - Chen, Hong Jun

AU - Boden-Albala, Bernadette

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AB - Objective: To show that serum interleukin levels are associated with carotid intima-media thickness (IMT). Background: Inflammation is hypothesized to play a central role in atherogenesis, and serum markers of inflammation are predictive of cardiovascular disease. Interleukin-2, a pro-inflammatory cytokine produced largely by naive CD4 T cells and Th1 (pro-inflammatory) T cells, has been found in a high proportion of carotid plaques. Methods: High-resolution ultrasound of the carotid arteries and serum cytokine levels were measured in stroke-free participants. The mean of the maximum IMT in bilateral bifurcation, common and internal carotid artery segments was measured. Serum levels of interleukin (IL)-1beta, IL-2, IL-6, C-reactive protein, tumor necrosis factor (TNF) alpha and TNF receptors were measured using enzyme-linked immunosorbent assay. Results: IL-2 levels were significantly correlated with IMT (r = 0.33, P < 0.0001), but other cytokines were not. Each unit increase in IL-2 was significantly associated with a mean increase in IMT of 0.18 mm (P = 0.0001). After adjusting for other atherosclerotic risk factors, the association was unchanged (mean increase in IMT per unit increase IL-2 = 0.18 mm, P < 0.0001). Each standard deviation increase in the level of IL-2 was associated with an increased risk (adjusted odds ratio 1.80, 95% CI 1.12-2.89) for an IMT ≥ 1.0 mm (75th percentile for IMT). Conclusion: Serum levels of IL-2, a pro-inflammatory cytokine, are associated with carotid artery IMT, a predictor of stroke and vascular disease. Serum inflammatory markers may provide a novel marker of atherosclerotic risk, and inflammation may provide a new therapeutic target for stroke prevention.

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