Interleukin-12 promotes recovery from viral encephalitis

Takashi Komatsu, Maria Barna, Carol S. Reiss

Research output: Contribution to journalArticle

Abstract

Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.

Original languageEnglish (US)
Pages (from-to)35-47
Number of pages13
JournalViral Immunology
Volume10
Issue number1
StatePublished - 1997

Fingerprint

Viral Encephalitis
Vesicular Stomatitis
Interleukin-12
Central Nervous System
Virus Diseases
Histocompatibility Antigens Class II
Major Histocompatibility Complex
Viral Load
Nitric Oxide Synthase
Interferons
Weight Loss
Tumor Necrosis Factor-alpha
Viruses
Antigens
Brain

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Interleukin-12 promotes recovery from viral encephalitis. / Komatsu, Takashi; Barna, Maria; Reiss, Carol S.

In: Viral Immunology, Vol. 10, No. 1, 1997, p. 35-47.

Research output: Contribution to journalArticle

Komatsu, T, Barna, M & Reiss, CS 1997, 'Interleukin-12 promotes recovery from viral encephalitis', Viral Immunology, vol. 10, no. 1, pp. 35-47.
Komatsu, Takashi ; Barna, Maria ; Reiss, Carol S. / Interleukin-12 promotes recovery from viral encephalitis. In: Viral Immunology. 1997 ; Vol. 10, No. 1. pp. 35-47.
@article{d028904c9dd44b4eb505464e36a7d0b9,
title = "Interleukin-12 promotes recovery from viral encephalitis",
abstract = "Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.",
author = "Takashi Komatsu and Maria Barna and Reiss, {Carol S.}",
year = "1997",
language = "English (US)",
volume = "10",
pages = "35--47",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "1",

}

TY - JOUR

T1 - Interleukin-12 promotes recovery from viral encephalitis

AU - Komatsu, Takashi

AU - Barna, Maria

AU - Reiss, Carol S.

PY - 1997

Y1 - 1997

N2 - Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.

AB - Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.

UR - http://www.scopus.com/inward/record.url?scp=0030928503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030928503&partnerID=8YFLogxK

M3 - Article

C2 - 9095530

AN - SCOPUS:0030928503

VL - 10

SP - 35

EP - 47

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 1

ER -