Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cristina Cantarutti, Gijo Raj, Federico Fogolari, Sofia Giorgetti, Alessandra Corazza, Vittorio Bellotti, Pance Naumov, Gennaro Esposito

    Research output: Contribution to journalArticle

    Abstract

    Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

    Original languageEnglish (US)
    Pages (from-to)5422-5425
    Number of pages4
    JournalChemical Communications
    Volume54
    Issue number43
    DOIs
    StatePublished - Jan 1 2018

    Fingerprint

    Citric Acid
    Gold
    Nanoparticles
    Proteins
    Oligomers
    Amyloidogenic Proteins
    Amyloid
    Nuclear magnetic resonance
    Experiments

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

    Cite this

    Cantarutti, C., Raj, G., Fogolari, F., Giorgetti, S., Corazza, A., Bellotti, V., ... Esposito, G. (2018). Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. Chemical Communications, 54(43), 5422-5425. https://doi.org/10.1039/c8cc01053f

    Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. / Cantarutti, Cristina; Raj, Gijo; Fogolari, Federico; Giorgetti, Sofia; Corazza, Alessandra; Bellotti, Vittorio; Naumov, Pance; Esposito, Gennaro.

    In: Chemical Communications, Vol. 54, No. 43, 01.01.2018, p. 5422-5425.

    Research output: Contribution to journalArticle

    Cantarutti, C, Raj, G, Fogolari, F, Giorgetti, S, Corazza, A, Bellotti, V, Naumov, P & Esposito, G 2018, 'Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association', Chemical Communications, vol. 54, no. 43, pp. 5422-5425. https://doi.org/10.1039/c8cc01053f
    Cantarutti C, Raj G, Fogolari F, Giorgetti S, Corazza A, Bellotti V et al. Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. Chemical Communications. 2018 Jan 1;54(43):5422-5425. https://doi.org/10.1039/c8cc01053f
    Cantarutti, Cristina ; Raj, Gijo ; Fogolari, Federico ; Giorgetti, Sofia ; Corazza, Alessandra ; Bellotti, Vittorio ; Naumov, Pance ; Esposito, Gennaro. / Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. In: Chemical Communications. 2018 ; Vol. 54, No. 43. pp. 5422-5425.
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