Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cristina Cantarutti, Gijo Raj, Federico Fogolari, Sofia Giorgetti, Alessandra Corazza, Vittorio Bellotti, Pance Naumov, Gennaro Esposito

Research output: Contribution to journalArticle

Abstract

Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

Original languageEnglish (US)
Pages (from-to)5422-5425
Number of pages4
JournalChemical Communications
Volume54
Issue number43
DOIs
StatePublished - Jan 1 2018

Fingerprint

Citric Acid
Gold
Nanoparticles
Proteins
Oligomers
Amyloidogenic Proteins
Amyloid
Nuclear magnetic resonance
Experiments

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. / Cantarutti, Cristina; Raj, Gijo; Fogolari, Federico; Giorgetti, Sofia; Corazza, Alessandra; Bellotti, Vittorio; Naumov, Pance; Esposito, Gennaro.

In: Chemical Communications, Vol. 54, No. 43, 01.01.2018, p. 5422-5425.

Research output: Contribution to journalArticle

Cantarutti C, Raj G, Fogolari F, Giorgetti S, Corazza A, Bellotti V et al. Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. Chemical Communications. 2018 Jan 1;54(43):5422-5425. https://doi.org/10.1039/c8cc01053f
Cantarutti, Cristina ; Raj, Gijo ; Fogolari, Federico ; Giorgetti, Sofia ; Corazza, Alessandra ; Bellotti, Vittorio ; Naumov, Pance ; Esposito, Gennaro. / Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. In: Chemical Communications. 2018 ; Vol. 54, No. 43. pp. 5422-5425.
@article{83f5a0fde2a0453ba618855c80eba8a6,
title = "Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association",
abstract = "Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.",
author = "Cristina Cantarutti and Gijo Raj and Federico Fogolari and Sofia Giorgetti and Alessandra Corazza and Vittorio Bellotti and Pance Naumov and Gennaro Esposito",
year = "2018",
month = "1",
day = "1",
doi = "10.1039/c8cc01053f",
language = "English (US)",
volume = "54",
pages = "5422--5425",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "43",

}

TY - JOUR

T1 - Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

AU - Cantarutti, Cristina

AU - Raj, Gijo

AU - Fogolari, Federico

AU - Giorgetti, Sofia

AU - Corazza, Alessandra

AU - Bellotti, Vittorio

AU - Naumov, Pance

AU - Esposito, Gennaro

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

AB - Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

UR - http://www.scopus.com/inward/record.url?scp=85047554218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047554218&partnerID=8YFLogxK

U2 - 10.1039/c8cc01053f

DO - 10.1039/c8cc01053f

M3 - Article

C2 - 29737327

AN - SCOPUS:85047554218

VL - 54

SP - 5422

EP - 5425

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 43

ER -