Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions

Research output: Contribution to journalArticle

Abstract

A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalJournal of Molecular Graphics
Volume3
Issue number2
DOIs
StatePublished - 1985

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Nucleic acids
nucleic acids
Nucleic Acids
Macros
manipulators
Connecting rods
Molecules
files
molecules
apexes
education
rods
Network protocols

Keywords

  • macromolecular architecture
  • nucleic acid junctions
  • sticky-ended ligation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

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title = "Interactive design and manipulation of macro-molecular architecture utilizing nucleic acid junctions",
abstract = "A program is introduced for the design of macromolecular structures using branched nucleic acid junctions as building blocks. This can result in unexpected features in the designed molecules, several examples of which are illustrated. The program allows interactive construction of models constrained by double-helical connecting rods between vertices. The logical structure of the design process is based on the single helical segment, rather than on the junction, as the fundamental unit. The file structure permits storage of both molecules and instruction protocols.",
keywords = "macromolecular architecture, nucleic acid junctions, sticky-ended ligation",
author = "Nadrian Seeman",
year = "1985",
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