Interactions between hippocampal serotonin and the pituitary-adrenal axis in the septal driving of hippocampal theta-rhythm

Efrain Azmitia, N. McNaughton, L. Tsaltas, M. Fillenz, J. A. Gray

Research output: Contribution to journalArticle

Abstract

Stimulation of the septal area at a frequency between 6 and 10 Hz is able to drive hippocampal theta. In freely moving male rats, the minimum threshold current for driving theta occurs at 7.7 Hz. Disruption of the pituitary-adrenal axis by injection of corticosterone to normal rats or by bilateral adrenalectomy (ADX) causes a shift of the minimum theta-driving threshold to 6.9 Hz. Corticosterone injection to ADX rats returns the minimum to 7.7 Hz. Specific and localized removal of hippocampal serotonergic fibers by intracerebral injections of 5,7-DHT) produces the same shift to a 6.9-Hz minimum threshold as does corticosterone or ADX. We further report that these effects of manipulating the adrenocortical and serotonergic systems act through related (or common) mechanisms since: (1) 5,7-DHT shift to 6.9 Hz can be reversed to 7.7 Hz by injection of corticosterone; (2) 5,7-DHT lesions in an ADX rat produce a normal theta threshold minimum at 7.7 Hz, and (3) in a combined ADX- and 5,7-DHT-lesioned rat, corticosterone again produces a 6.9-Hz minimum as this hormone does in normal rats. These results suggest that the serotonergic inputs to the hippocampus interact with the same neurons which concentrate corticosterone.

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalNeuroendocrinology
Volume39
Issue number5
StatePublished - 1984

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Theta Rhythm
Corticosterone
Serotonin
Injections
Septum of Brain
Adrenalectomy
Hippocampus
Hormones
Neurons

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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Interactions between hippocampal serotonin and the pituitary-adrenal axis in the septal driving of hippocampal theta-rhythm. / Azmitia, Efrain; McNaughton, N.; Tsaltas, L.; Fillenz, M.; Gray, J. A.

In: Neuroendocrinology, Vol. 39, No. 5, 1984, p. 471-475.

Research output: Contribution to journalArticle

Azmitia, Efrain ; McNaughton, N. ; Tsaltas, L. ; Fillenz, M. ; Gray, J. A. / Interactions between hippocampal serotonin and the pituitary-adrenal axis in the septal driving of hippocampal theta-rhythm. In: Neuroendocrinology. 1984 ; Vol. 39, No. 5. pp. 471-475.
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