Interactions between chronic renal disease and periodontal disease

Research output: Contribution to journalArticle

Abstract

The incidence of end-stage renal disease (ESRD) is increasing and patients receiving renal replacement therapy including hemodialysis, peritoneal dialysis or renal transplantation will comprise an enlarging segment of the dental patient population. Renal replacement therapy can affect periodontal tissues including gingival hyperplasia in immune suppressed renal transplantation patients and increased levels of plaque, calculus and gingival inflammation and possible increased prevalence and severity of destructive periodontal diseases in ESRD patients on dialysis maintenance therapy. Also, the presence of undiagnosed periodontitis may have significant effects on the medical management of the ESRD patient. Periodontitis has been found to contribute to systemic inflammatory burden including the elevation of C-reactive protein (CRP) in the general population. Atherosclerotic complications including myocardial infarction and stroke are the primary causes of mortality in the ESRD population and, in contrast to that of the general population, the best predictor of all cause and cardiac death in this population is CRP. Consequently, periodontitis may be a covert but treatable source of systemic inflammation in the ESRD population. The objective of this review was to explore the interaction between chronic renal disease, renal replacement therapy and periodontal diseases based upon the results of studies published within the last decade.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalOral Diseases
Volume14
Issue number1
DOIs
StatePublished - Jan 2008

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Periodontal Diseases
Chronic Renal Insufficiency
Chronic Kidney Failure
Renal Replacement Therapy
Periodontitis
Population
C-Reactive Protein
Kidney Transplantation
Gingival Hyperplasia
Inflammation
Calculi
Peritoneal Dialysis
Renal Dialysis
Dialysis
Cause of Death
Tooth
Stroke
Myocardial Infarction
Mortality
Incidence

Keywords

  • End stage renal disease
  • Hemodialysis
  • Periodontal diseases
  • Periodontitis
  • Peritoneal dialysis
  • Renal transplantation

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Interactions between chronic renal disease and periodontal disease. / Craig, Ronald.

In: Oral Diseases, Vol. 14, No. 1, 01.2008, p. 1-7.

Research output: Contribution to journalArticle

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