Integrative predictive model of coronary artery calcification in atherosclerosis

Michael McGeachie, Rachel L. Badovinac Ramoni, Josyf C. Mychaleckyj, Karen L. Furie, Jonathan M. Dreyfuss, Yongmei Liu, David Herrington, Xiuqing Guo, João A. Lima, Wendy Post, Jerome I. Rotter, Stephen Rich, Michèle Sale, Marco F. Ramoni

Research output: Contribution to journalArticle

Abstract

Background-: Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. We present a model of preclinical atherosclerosis based on genetic and clinical data that predicts the presence of coronary artery calcification in healthy Americans of European descent 45 to 84 years of age in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods and Results-: We assessed 712 individuals for the presence or absence of coronary artery calcification and assessed their genotypes for 2882 single-nucleotide polymorphisms. With the use of these single-nucleotide polymorphisms and relevant clinical data, a Bayesian network that predicts the presence of coronary calcification was constructed. The model contained 13 single-nucleotide polymorphisms (from genes AGTR1, ALOX15, INSR, PRKAB1, IL1R2, ESR2, KCNK1, FBLN5, PPARA, VEGFA, PON1, TDRD6, PLA2G7, and 1 ancestry informative marker) and 5 clinical variables (sex, age, weight, smoking, and diabetes mellitus) and achieved 85% predictive accuracy, as measured by area under the receiver operating characteristic curve. This is a significant (P

Original languageEnglish (US)
Pages (from-to)2448-2454
Number of pages7
JournalCirculation
Volume120
Issue number24
DOIs
StatePublished - Dec 2009

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Single Nucleotide Polymorphism
Atherosclerosis
Coronary Vessels
ROC Curve
Diabetes Mellitus
Biomarkers
Smoking
Genotype
Weights and Measures
Genes

Keywords

  • Atherosclerosis
  • Genetics
  • Risk factors

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

McGeachie, M., Badovinac Ramoni, R. L., Mychaleckyj, J. C., Furie, K. L., Dreyfuss, J. M., Liu, Y., ... Ramoni, M. F. (2009). Integrative predictive model of coronary artery calcification in atherosclerosis. Circulation, 120(24), 2448-2454. https://doi.org/10.1161/CIRCULATIONAHA.109.865501

Integrative predictive model of coronary artery calcification in atherosclerosis. / McGeachie, Michael; Badovinac Ramoni, Rachel L.; Mychaleckyj, Josyf C.; Furie, Karen L.; Dreyfuss, Jonathan M.; Liu, Yongmei; Herrington, David; Guo, Xiuqing; Lima, João A.; Post, Wendy; Rotter, Jerome I.; Rich, Stephen; Sale, Michèle; Ramoni, Marco F.

In: Circulation, Vol. 120, No. 24, 12.2009, p. 2448-2454.

Research output: Contribution to journalArticle

McGeachie, M, Badovinac Ramoni, RL, Mychaleckyj, JC, Furie, KL, Dreyfuss, JM, Liu, Y, Herrington, D, Guo, X, Lima, JA, Post, W, Rotter, JI, Rich, S, Sale, M & Ramoni, MF 2009, 'Integrative predictive model of coronary artery calcification in atherosclerosis', Circulation, vol. 120, no. 24, pp. 2448-2454. https://doi.org/10.1161/CIRCULATIONAHA.109.865501
McGeachie M, Badovinac Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y et al. Integrative predictive model of coronary artery calcification in atherosclerosis. Circulation. 2009 Dec;120(24):2448-2454. https://doi.org/10.1161/CIRCULATIONAHA.109.865501
McGeachie, Michael ; Badovinac Ramoni, Rachel L. ; Mychaleckyj, Josyf C. ; Furie, Karen L. ; Dreyfuss, Jonathan M. ; Liu, Yongmei ; Herrington, David ; Guo, Xiuqing ; Lima, João A. ; Post, Wendy ; Rotter, Jerome I. ; Rich, Stephen ; Sale, Michèle ; Ramoni, Marco F. / Integrative predictive model of coronary artery calcification in atherosclerosis. In: Circulation. 2009 ; Vol. 120, No. 24. pp. 2448-2454.
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