Integrated analysis of gene network in childhood leukemia from microarray and pathway databases

Amphun Chaiboonchoe, Sandhya Samarasinghe, Don Kulasiri, Kourosh Salehi-Ashtiani

    Research output: Contribution to journalArticle

    Abstract

    Glucocorticoids (GCs) have been used as therapeutic agents for children with acute lymphoblastic leukaemia (ALL) for over 50 years. However, much remains to be understood about the molecular mechanism of GCs actions in ALL subtypes. In this study, we delineate differential responses of ALL subtypes, B- and T-ALL, to GCs treatment at systems level by identifying the differences among biological processes, molecular pathways, and interaction networks that emerge from the action of GCs through the use of a selected number of available bioinformatics methods and tools. We provide biological insight into GC-regulated genes, their related functions, and their networks specific to the ALL subtypes. We show that differentially expressed GC-regulated genes participate in distinct underlying biological processes affected by GCs in B-ALL and T-ALL with little to no overlap. These findings provide the opportunity towards identifying new therapeutic targets.

    Original languageEnglish (US)
    Article number278748
    JournalBioMed Research International
    Volume2014
    DOIs
    StatePublished - Jan 1 2014

    Fingerprint

    Gene Regulatory Networks
    Microarrays
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Glucocorticoids
    Leukemia
    Genes
    Databases
    Biological Phenomena
    Bioinformatics
    Computational Biology
    Therapeutics

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Immunology and Microbiology(all)
    • Medicine(all)

    Cite this

    Integrated analysis of gene network in childhood leukemia from microarray and pathway databases. / Chaiboonchoe, Amphun; Samarasinghe, Sandhya; Kulasiri, Don; Salehi-Ashtiani, Kourosh.

    In: BioMed Research International, Vol. 2014, 278748, 01.01.2014.

    Research output: Contribution to journalArticle

    Chaiboonchoe, Amphun ; Samarasinghe, Sandhya ; Kulasiri, Don ; Salehi-Ashtiani, Kourosh. / Integrated analysis of gene network in childhood leukemia from microarray and pathway databases. In: BioMed Research International. 2014 ; Vol. 2014.
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