Insulin-like growth factor-I: Compartmentalization within the somatotropic axis?

Andrew A. Butler, Shoshana Yakar, Derek LeRoith

Research output: Contribution to journalArticle


Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalNews in Physiological Sciences
Issue number2
StatePublished - Apr 1 2002


ASJC Scopus subject areas

  • Physiology

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