Insulin-like growth factor-I: Compartmentalization within the somatotropic axis?

Andrew A. Butler, Shoshana Yakar, Derek LeRoith

Research output: Contribution to journalArticle

Abstract

Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalNews in Physiological Sciences
Volume17
Issue number2
StatePublished - Apr 2002

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Insulin-Like Growth Factor I
Growth
Gene Targeting
Technology
Mutation
Liver
Genes

ASJC Scopus subject areas

  • Physiology

Cite this

Insulin-like growth factor-I : Compartmentalization within the somatotropic axis? / Butler, Andrew A.; Yakar, Shoshana; LeRoith, Derek.

In: News in Physiological Sciences, Vol. 17, No. 2, 04.2002, p. 82-85.

Research output: Contribution to journalArticle

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