Insulin-Like Growth Factor 1 Physiology. Lessons from Mouse Models.

Shoshana Yakar, Martin L. Adamo

Research output: Contribution to journalArticle

Abstract

Insulin-like growth factor 1 (IGF-1) is a pleiotropic polypeptide. Its expression is tightly regulated and it plays significant roles during early development, maturation, and adulthood. This article discusses the roles of IGF-1 in determination of body size, skeletal acquisition, muscle growth, carbohydrate metabolism, and longevity, as learned from mouse models.

Original languageEnglish (US)
Pages (from-to)231-247
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Volume41
Issue number2
DOIs
StatePublished - Jun 2012

Fingerprint

Somatomedins
Carbohydrate Metabolism
Body Size
Skeletal Muscle
Peptides
Growth

Keywords

  • IGF-1
  • Insulin-like growth factor 1
  • Mouse models
  • Physiology

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin-Like Growth Factor 1 Physiology. Lessons from Mouse Models. / Yakar, Shoshana; Adamo, Martin L.

In: Endocrinology and Metabolism Clinics of North America, Vol. 41, No. 2, 06.2012, p. 231-247.

Research output: Contribution to journalArticle

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