Innate immunity in viral encephalitis: Role of C5

Research output: Contribution to journalArticle

Abstract

The complement system is a critical component of both the innate and acquired immune systems. It is important in host defense against viruses, bacteria, and fungi for opsonization and for lysis of pathogens. However, activated complement can also cause tissue damage. There is compelling evidence that complement factors are presented in the central nervous system (CNS). Complement activation (by any of the three pathways: classical, alternate, and lectin) can lead to inflammation and tissue damage, while at the same time may also restrict certain pathogens in the CNS. C5a is formed by proteolytic cleavage C5. C5a is considered the most potent proinflammatory mediator, often called an anaphylotoxin. In this communication, we examine the roles of C5 (C5a) in vesicular stomatitis virus (VSV)-induced encephalitis. We found that C5a is produced during VSV infection, but C5-deficient mice had similar pathology as their controls. We concluded that C5 is not a critical factor in mediating the host response during VSV encephalitis.

Original languageEnglish (US)
Pages (from-to)365-372
Number of pages8
JournalViral Immunology
Volume15
Issue number2
StatePublished - 2002

Fingerprint

Viral Encephalitis
Vesicular Stomatitis
Encephalitis Viruses
Innate Immunity
Central Nervous System
Complement Activation
Virus Diseases
Lectins
Immune System
Fungi
Pathology
Viruses
Inflammation
Bacteria

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Innate immunity in viral encephalitis : Role of C5. / Chen, Nannan; Reiss, Carol Shoshkes.

In: Viral Immunology, Vol. 15, No. 2, 2002, p. 365-372.

Research output: Contribution to journalArticle

@article{19406a654e6345aea519a98e764a165d,
title = "Innate immunity in viral encephalitis: Role of C5",
abstract = "The complement system is a critical component of both the innate and acquired immune systems. It is important in host defense against viruses, bacteria, and fungi for opsonization and for lysis of pathogens. However, activated complement can also cause tissue damage. There is compelling evidence that complement factors are presented in the central nervous system (CNS). Complement activation (by any of the three pathways: classical, alternate, and lectin) can lead to inflammation and tissue damage, while at the same time may also restrict certain pathogens in the CNS. C5a is formed by proteolytic cleavage C5. C5a is considered the most potent proinflammatory mediator, often called an anaphylotoxin. In this communication, we examine the roles of C5 (C5a) in vesicular stomatitis virus (VSV)-induced encephalitis. We found that C5a is produced during VSV infection, but C5-deficient mice had similar pathology as their controls. We concluded that C5 is not a critical factor in mediating the host response during VSV encephalitis.",
author = "Nannan Chen and Reiss, {Carol Shoshkes}",
year = "2002",
language = "English (US)",
volume = "15",
pages = "365--372",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

TY - JOUR

T1 - Innate immunity in viral encephalitis

T2 - Role of C5

AU - Chen, Nannan

AU - Reiss, Carol Shoshkes

PY - 2002

Y1 - 2002

N2 - The complement system is a critical component of both the innate and acquired immune systems. It is important in host defense against viruses, bacteria, and fungi for opsonization and for lysis of pathogens. However, activated complement can also cause tissue damage. There is compelling evidence that complement factors are presented in the central nervous system (CNS). Complement activation (by any of the three pathways: classical, alternate, and lectin) can lead to inflammation and tissue damage, while at the same time may also restrict certain pathogens in the CNS. C5a is formed by proteolytic cleavage C5. C5a is considered the most potent proinflammatory mediator, often called an anaphylotoxin. In this communication, we examine the roles of C5 (C5a) in vesicular stomatitis virus (VSV)-induced encephalitis. We found that C5a is produced during VSV infection, but C5-deficient mice had similar pathology as their controls. We concluded that C5 is not a critical factor in mediating the host response during VSV encephalitis.

AB - The complement system is a critical component of both the innate and acquired immune systems. It is important in host defense against viruses, bacteria, and fungi for opsonization and for lysis of pathogens. However, activated complement can also cause tissue damage. There is compelling evidence that complement factors are presented in the central nervous system (CNS). Complement activation (by any of the three pathways: classical, alternate, and lectin) can lead to inflammation and tissue damage, while at the same time may also restrict certain pathogens in the CNS. C5a is formed by proteolytic cleavage C5. C5a is considered the most potent proinflammatory mediator, often called an anaphylotoxin. In this communication, we examine the roles of C5 (C5a) in vesicular stomatitis virus (VSV)-induced encephalitis. We found that C5a is produced during VSV infection, but C5-deficient mice had similar pathology as their controls. We concluded that C5 is not a critical factor in mediating the host response during VSV encephalitis.

UR - http://www.scopus.com/inward/record.url?scp=0035987442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035987442&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 365

EP - 372

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 2

ER -